Product Information
SYSTANE HYDRATION PF 0.4-0.3% is a brand product labeled by Alcon Laboratories, Inc., priced at $0.3736 per EA under NDC 00065143704. Its NADAC has been published 322 times since Apr 29, 2020.
Strength
4; 3 mg/mL; mg/mL
Manufacturer
Alcon Laboratories, Inc.NDC
00065143704
Classification
Brand
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Last Updated
6/17/2026
Active Ingredients
POLYETHYLENE GLYCOL 400; PROPYLENE GLYCOLApproval Type
OTC MONOGRAPH DRUG
FDA Application
M018On Market Since
2/1/2020
Price Statistics
The NADAC for SYSTANE HYDRATION PF 0.4-0.3% has been published 322 times since Apr 29, 2020, and over the history we have for it it has risen 12.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.3736 per EA |
|---|---|
| All-time high | $0.4900 (Mar 11, 2026) |
| All-time low | $0.3248 (May 20, 2020) |
| 52-week high | $0.4900 |
| 52-week low | $0.3715 |
| Median price | $0.3661 |
| Average price | $0.3635 |
| Largest weekly change | +29.1% (Dec 17, 2025) |
| Weeks tracked | 322 |
| Tracking since | Apr 29, 2020 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient, strength, and dosage form. Compare the broader picture on the Polyethylene Glycol 400 and Propylene Glycol market page.
Lowest-Cost Alternatives
No alternatives available
Frequently asked questions
What is the NADAC price of SYSTANE HYDRATION PF 0.4-0.3%?
The current National Average Drug Acquisition Cost (NADAC) for SYSTANE HYDRATION PF 0.4-0.3%, manufactured by Alcon Laboratories, Inc., is $0.3736 per EA (NDC 00065143704), effective Jun 24, 2026.
How has the price of SYSTANE HYDRATION PF 0.4-0.3% changed over time?
Over the history we have for it, the NADAC for SYSTANE HYDRATION PF 0.4-0.3% has risen 12.0%. It has been tracked across 322 weekly CMS publications since Apr 29, 2020.
What are the highest and lowest recorded NADAC prices for SYSTANE HYDRATION PF 0.4-0.3%?
Since Apr 29, 2020, the NADAC for SYSTANE HYDRATION PF 0.4-0.3% has ranged from a low of $0.3248 (May 20, 2020) to a high of $0.4900 (Mar 11, 2026), with a median of $0.3661 per EA.
Are there cheaper alternatives to SYSTANE HYDRATION PF 0.4-0.3%?
No other NADAC-published product currently shares the active ingredient, strength, and dosage form of SYSTANE HYDRATION PF 0.4-0.3%, so no direct lower-cost alternative is listed.
Who manufactures SYSTANE HYDRATION PF 0.4-0.3%?
SYSTANE HYDRATION PF 0.4-0.3% (NDC 00065143704) is labeled by Alcon Laboratories, Inc., and CMS classifies it as a brand product.
Related Drugs
Same classification