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Product Information

SYSTANE HYDRATION PF 0.4-0.3% is a brand product labeled by Alcon Laboratories, Inc., priced at $0.3762 per EA under NDC 00065143704. Its NADAC has been published 336 times since Apr 29, 2020.

SYSTANE HYDRATION PF 0.4-0.3%

Polyethylene Glycol 400 and Propylene Glycol
$0.3762per EA
OTC

Strength

4; 3 mg/mL; mg/mL

NDC

00065143704

Classification

Brand

Dosage Form

SOLUTION/ DROPS

Route

OPHTHALMIC

Effective Date

9/23/2026

Approval Type

OTC MONOGRAPH DRUG

FDA Application

M018

On Market Since

2/1/2020

Price Statistics

The NADAC for SYSTANE HYDRATION PF 0.4-0.3% has been published 336 times since Apr 29, 2020, and over the history we have for it it has risen 12.8%. The table below summarizes its recorded NADAC range and movement.

Current price$0.3762 per EA
All-time high$0.4900 (Mar 11, 2026)
All-time low$0.3248 (May 20, 2020)
52-week high$0.4900
52-week low$0.3734
Median price$0.3663
Average price$0.3640
Largest weekly change+29.1% (Dec 17, 2025)
Weeks tracked336
Tracking sinceApr 29, 2020

Price History

1W

0.0%

1M

+0.2%

3M

+0.7%

6M

+0.2%

1Y

+0.3%

3Y

+2.9%

5Y

+9.3%

All

+12.8%

Generic Alternatives

No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Polyethylene Glycol 400 and Propylene Glycol market page.

Lowest-Cost Alternatives

No alternatives available

No alternatives found with the same active ingredient and strength in a comparable dosage form.

Related Drugs

Same classification

No related drugs found.

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Manufacturer

Alcon Laboratories, Inc. manufacturer profile

See the full portfolio, pricing trend, and other products from this labeler.

Drug market

Polyethylene Glycol 400 and Propylene Glycol market comparison

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Trend hub

Latest market trends

Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.

Guide

Understanding NADAC pricing

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Frequently asked questions

What is the NADAC price of SYSTANE HYDRATION PF 0.4-0.3%?

The current National Average Drug Acquisition Cost (NADAC) for SYSTANE HYDRATION PF 0.4-0.3%, manufactured by Alcon Laboratories, Inc., is $0.3762 per EA (NDC 00065143704), effective Sep 30, 2026.

How has the price of SYSTANE HYDRATION PF 0.4-0.3% changed over time?

Over the history we have for it, the NADAC for SYSTANE HYDRATION PF 0.4-0.3% has risen 12.8%. It has been tracked across 336 weekly CMS publications since Apr 29, 2020.

What are the highest and lowest recorded NADAC prices for SYSTANE HYDRATION PF 0.4-0.3%?

Since Apr 29, 2020, the NADAC for SYSTANE HYDRATION PF 0.4-0.3% has ranged from a low of $0.3248 (May 20, 2020) to a high of $0.4900 (Mar 11, 2026), with a median of $0.3663 per EA.

Are there cheaper alternatives to SYSTANE HYDRATION PF 0.4-0.3%?

No other NADAC-published product currently shares the active ingredient and strength of SYSTANE HYDRATION PF 0.4-0.3% in a comparable dosage form, so no direct lower-cost alternative is listed.

Who manufactures SYSTANE HYDRATION PF 0.4-0.3%?

SYSTANE HYDRATION PF 0.4-0.3% (NDC 00065143704) is labeled by Alcon Laboratories, Inc., and CMS classifies it as a brand product.