Product Information
NITROGLYCERIN 0.4% OINTMENT is a generic product labeled by Encube Ethicals, Inc., priced at $8.3149 per GM under NDC 21922004805. Its NADAC has been published 80 times since Mar 26, 2025.
FDA first approved this application on Dec 16, 2024. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
4 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922004805
Classification
Generic
Dosage Form
OINTMENT
Route
RECTAL
Effective Date
9/23/2026
Active Ingredients
NITROGLYCERINApproval Type
Generic (ANDA)
FDA Application
ANDA216452FDA Approved
12/16/2024
TE Code
AB
On Market Since
12/17/2024
Pharmacological Classes
Price Statistics
The NADAC for NITROGLYCERIN 0.4% OINTMENT has been published 80 times since Mar 26, 2025, and over the history we have for it it has declined 40.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.3149 per GM |
|---|---|
| All-time high | $15.8173 (Jun 11, 2025) |
| All-time low | $8.3149 (Sep 23, 2026) |
| 52-week high | $13.4439 |
| 52-week low | $8.3149 |
| Median price | $12.7546 |
| Average price | $12.0611 |
| Largest weekly change | -14.3% (Apr 22, 2026) |
| Weeks tracked | 80 |
| Tracking since | Mar 26, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
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Drug market
Nitroglycerin market comparison
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Therapeutic class
Nitrate Vasodilator class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of NITROGLYCERIN 0.4% OINTMENT?
The current National Average Drug Acquisition Cost (NADAC) for NITROGLYCERIN 0.4% OINTMENT, manufactured by Encube Ethicals, Inc., is $8.3149 per GM (NDC 21922004805), effective Sep 30, 2026.
How has the price of NITROGLYCERIN 0.4% OINTMENT changed over time?
Over the history we have for it, the NADAC for NITROGLYCERIN 0.4% OINTMENT has declined 40.9%. It has been tracked across 80 weekly CMS publications since Mar 26, 2025.
What are the highest and lowest recorded NADAC prices for NITROGLYCERIN 0.4% OINTMENT?
Since Mar 26, 2025, the NADAC for NITROGLYCERIN 0.4% OINTMENT has ranged from a low of $8.3149 (Sep 23, 2026) to a high of $15.8173 (Jun 11, 2025), with a median of $12.7546 per GM.
Are there cheaper alternatives to NITROGLYCERIN 0.4% OINTMENT?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as NITROGLYCERIN 0.4% OINTMENT in a comparable dosage form, but none are currently priced below it.
Who manufactures NITROGLYCERIN 0.4% OINTMENT?
NITROGLYCERIN 0.4% OINTMENT (NDC 21922004805) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.