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Product Information

ENBREL 25 MG/0.5 ML SYRINGE is a brand product labeled by Immunex Corporation, priced at $2086.2042 per ML under NDC 58406001004. Its NADAC has been published 331 times since Jan 22, 2020.

ENBREL 25 MG/0.5 ML SYRINGE

etanercept
$2086.2042per ML

Strength

25 mg/.5mL

NDC

58406001004

Classification

Brand

Dosage Form

SOLUTION

Route

SUBCUTANEOUS

Effective Date

8/19/2026

Active Ingredients

ETANERCEPT

Approval Type

Biologic (BLA)

FDA Application

BLA103795

On Market Since

6/7/2019

Pharmacological Classes

Tumor Necrosis Factor Blocker
Tumor Necrosis Factor Receptor Blocking Activity

Price Statistics

The NADAC for ENBREL 25 MG/0.5 ML SYRINGE has been published 331 times since Jan 22, 2020, and over the history we have for it it has risen 65.3%. The table below summarizes its recorded NADAC range and movement.

Current price$2086.2042 per ML
All-time high$2086.2042 (Aug 19, 2026)
All-time low$1261.8250 (Jan 22, 2020)
52-week high$2086.2042
52-week low$1977.1488
Median price$1715.6364
Average price$1698.9817
Largest weekly change+7.4% (Jan 11, 2023)
Weeks tracked331
Tracking sinceJan 22, 2020

Price History

1W

0.0%

1M

0.0%

3M

+0.5%

6M

+0.5%

1Y

+5.3%

3Y

+21.6%

5Y

+43.6%

All

+65.3%

Generic Alternatives

No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the etanercept market page.

Lowest-Cost Alternatives

No alternatives available

No alternatives found with the same active ingredient and strength in a comparable dosage form.

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Frequently asked questions

What is the NADAC price of ENBREL 25 MG/0.5 ML SYRINGE?

The current National Average Drug Acquisition Cost (NADAC) for ENBREL 25 MG/0.5 ML SYRINGE, manufactured by Immunex Corporation, is $2086.2042 per ML (NDC 58406001004), effective Aug 19, 2026.

How has the price of ENBREL 25 MG/0.5 ML SYRINGE changed over time?

Over the history we have for it, the NADAC for ENBREL 25 MG/0.5 ML SYRINGE has risen 65.3%. It has been tracked across 331 weekly CMS publications since Jan 22, 2020.

What are the highest and lowest recorded NADAC prices for ENBREL 25 MG/0.5 ML SYRINGE?

Since Jan 22, 2020, the NADAC for ENBREL 25 MG/0.5 ML SYRINGE has ranged from a low of $1261.8250 (Jan 22, 2020) to a high of $2086.2042 (Aug 19, 2026), with a median of $1715.6364 per ML.

Are there cheaper alternatives to ENBREL 25 MG/0.5 ML SYRINGE?

No other NADAC-published product currently shares the active ingredient and strength of ENBREL 25 MG/0.5 ML SYRINGE in a comparable dosage form, so no direct lower-cost alternative is listed.

Who manufactures ENBREL 25 MG/0.5 ML SYRINGE?

ENBREL 25 MG/0.5 ML SYRINGE (NDC 58406001004) is labeled by Immunex Corporation, and CMS classifies it as a brand product.