Product Information
ENBREL 25 MG/0.5 ML SYRINGE is a brand product labeled by Immunex Corporation, priced at $2084.1443 per ML under NDC 58406001004. Its NADAC has been published 337 times since Jan 22, 2020.
Strength
25 mg/.5mL
Manufacturer
Immunex CorporationNDC
58406001004
Classification
Brand
Dosage Form
SOLUTION
Route
SUBCUTANEOUS
Effective Date
9/23/2026
Active Ingredients
ETANERCEPTApproval Type
Biologic (BLA)
FDA Application
BLA103795On Market Since
6/7/2019
Pharmacological Classes
Price Statistics
The NADAC for ENBREL 25 MG/0.5 ML SYRINGE has been published 337 times since Jan 22, 2020, and over the history we have for it it has risen 65.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2084.1443 per ML |
|---|---|
| All-time high | $2086.2042 (Sep 16, 2026) |
| All-time low | $1261.8250 (Jan 22, 2020) |
| 52-week high | $2086.2042 |
| 52-week low | $1977.1488 |
| Median price | $1715.6364 |
| Average price | $1705.8636 |
| Largest weekly change | +7.4% (Jan 11, 2023) |
| Weeks tracked | 337 |
| Tracking since | Jan 22, 2020 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the etanercept market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
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Manufacturer
Immunex Corporation manufacturer profile
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Drug market
etanercept market comparison
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Therapeutic class
Tumor Necrosis Factor Blocker class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ENBREL 25 MG/0.5 ML SYRINGE?
The current National Average Drug Acquisition Cost (NADAC) for ENBREL 25 MG/0.5 ML SYRINGE, manufactured by Immunex Corporation, is $2084.1443 per ML (NDC 58406001004), effective Sep 30, 2026.
How has the price of ENBREL 25 MG/0.5 ML SYRINGE changed over time?
Over the history we have for it, the NADAC for ENBREL 25 MG/0.5 ML SYRINGE has risen 65.2%. It has been tracked across 337 weekly CMS publications since Jan 22, 2020.
What are the highest and lowest recorded NADAC prices for ENBREL 25 MG/0.5 ML SYRINGE?
Since Jan 22, 2020, the NADAC for ENBREL 25 MG/0.5 ML SYRINGE has ranged from a low of $1261.8250 (Jan 22, 2020) to a high of $2086.2042 (Sep 16, 2026), with a median of $1715.6364 per ML.
Are there cheaper alternatives to ENBREL 25 MG/0.5 ML SYRINGE?
No other NADAC-published product currently shares the active ingredient and strength of ENBREL 25 MG/0.5 ML SYRINGE in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures ENBREL 25 MG/0.5 ML SYRINGE?
ENBREL 25 MG/0.5 ML SYRINGE (NDC 58406001004) is labeled by Immunex Corporation, and CMS classifies it as a brand product.