Product Information
UREA 40% CREAM is a generic product labeled by Method Pharmaceuticals LLC, priced at $0.3283 per GM under NDC 58657048703. Its NADAC has been published 96 times since Apr 6, 2022.
Strength
400 mg/g
Manufacturer
Method Pharmaceuticals LLCNDC
58657048703
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/20/2025
Active Ingredients
UREAApproval Type
Unapproved
On Market Since
11/15/2021
Price Statistics
The NADAC for UREA 40% CREAM has been published 96 times since Apr 6, 2022, and over the history we have for it it has declined 57.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.3283 per GM |
|---|---|
| All-time high | $0.7690 (Sep 14, 2022) |
| All-time low | $0.3283 (Aug 20, 2025) |
| Median price | $0.3919 |
| Average price | $0.4799 |
| Largest weekly change | -43.2% (Apr 17, 2024) |
| Weeks tracked | 96 |
| Tracking since | Apr 6, 2022 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
N/A
3Y
-57.3%
5Y
N/A
All
-57.3%
Last surveyed Aug 27, 2025 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 55% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Method Pharmaceuticals LLC manufacturer profile
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Drug market
Urea market comparison
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Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of UREA 40% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for UREA 40% CREAM, manufactured by Method Pharmaceuticals LLC, is $0.3283 per GM (NDC 58657048703), effective Aug 27, 2025.
How has the price of UREA 40% CREAM changed over time?
Over the history we have for it, the NADAC for UREA 40% CREAM has declined 57.3%. It has been tracked across 96 weekly CMS publications since Apr 6, 2022.
What are the highest and lowest recorded NADAC prices for UREA 40% CREAM?
Since Apr 6, 2022, the NADAC for UREA 40% CREAM has ranged from a low of $0.3283 (Aug 20, 2025) to a high of $0.7690 (Sep 14, 2022), with a median of $0.3919 per GM.
Are there cheaper alternatives to UREA 40% CREAM?
Yes. 4 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, UREA 40% CREAM, is $0.1462 per GM — about 55% below UREA 40% CREAM.
Who manufactures UREA 40% CREAM?
UREA 40% CREAM (NDC 58657048703) is labeled by Method Pharmaceuticals LLC, and CMS classifies it as a generic product.