Product Information
XIFAXAN 550 MG TABLET is a brand product labeled by Salix Pharmaceuticals Inc., priced at $55.2802 per EA under NDC 65649030303. Its NADAC has been published 619 times since Nov 28, 2013.
FDA first approved this application on May 25, 2004. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
550 mg/1
Manufacturer
Salix Pharmaceuticals Inc.NDC
65649030303
Classification
Brand
Dosage Form
TABLET
Route
ORAL
Effective Date
9/17/2025
Active Ingredients
RIFAXIMINApproval Type
New Drug (NDA)
FDA Application
NDA021361FDA Approved
5/25/2004
TE Code
AB
On Market Since
5/1/2010
Pharmacological Classes
Price Statistics
The NADAC for XIFAXAN 550 MG TABLET has been published 619 times since Nov 28, 2013, and over the history we have for it it has risen 158.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $55.2802 per EA |
|---|---|
| All-time high | $55.3506 (May 14, 2025) |
| All-time low | $21.2481 (May 21, 2014) |
| 52-week high | $55.2805 |
| 52-week low | $55.2802 |
| Median price | $37.9173 |
| Average price | $38.9612 |
| Largest weekly change | +9.0% (Feb 11, 2015) |
| Weeks tracked | 619 |
| Tracking since | Nov 28, 2013 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
-0.0%
3Y
+9.2%
5Y
+25.2%
All
+158.7%
Last surveyed Oct 1, 2025 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of XIFAXAN 550 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for XIFAXAN 550 MG TABLET, manufactured by Salix Pharmaceuticals Inc., is $55.2802 per EA (NDC 65649030303), effective Oct 1, 2025.
How has the price of XIFAXAN 550 MG TABLET changed over time?
Over the history we have for it, the NADAC for XIFAXAN 550 MG TABLET has risen 158.7%. It has been tracked across 619 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for XIFAXAN 550 MG TABLET?
Since Nov 28, 2013, the NADAC for XIFAXAN 550 MG TABLET has ranged from a low of $21.2481 (May 21, 2014) to a high of $55.3506 (May 14, 2025), with a median of $37.9173 per EA.
Are there cheaper alternatives to XIFAXAN 550 MG TABLET?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as XIFAXAN 550 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures XIFAXAN 550 MG TABLET?
XIFAXAN 550 MG TABLET (NDC 65649030303) is labeled by Salix Pharmaceuticals Inc., and CMS classifies it as a brand product.