Product Information
DIFLUPREDNATE 0.05% EYE DROP is a generic product labeled by Amneal Pharmaceuticals NY LLC, priced at $9.6866 per ML under NDC 69238138003. Its NADAC has been published 237 times since Mar 23, 2022.
FDA first approved this application on Nov 17, 2021. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/mL
Manufacturer
Amneal Pharmaceuticals NY LLCNDC
69238138003
Classification
Generic
Dosage Form
EMULSION
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
DIFLUPREDNATEApproval Type
Generic (ANDA)
FDA Application
ANDA211526FDA Approved
11/17/2021
TE Code
AB
On Market Since
11/18/2021
Price Statistics
The NADAC for DIFLUPREDNATE 0.05% EYE DROP has been published 237 times since Mar 23, 2022, and over the history we have for it it has declined 69.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $9.6866 per ML |
|---|---|
| All-time high | $31.8469 (Apr 13, 2022) |
| All-time low | $7.0479 (Jun 17, 2026) |
| 52-week high | $10.4599 |
| 52-week low | $7.0479 |
| Median price | $14.3011 |
| Average price | $15.1867 |
| Largest weekly change | +46.0% (Aug 21, 2024) |
| Weeks tracked | 237 |
| Tracking since | Mar 23, 2022 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Difluprednate ophthalmic market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Amneal Pharmaceuticals NY LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Difluprednate ophthalmic market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DIFLUPREDNATE 0.05% EYE DROP?
The current National Average Drug Acquisition Cost (NADAC) for DIFLUPREDNATE 0.05% EYE DROP, manufactured by Amneal Pharmaceuticals NY LLC, is $9.6866 per ML (NDC 69238138003), effective Sep 30, 2026.
How has the price of DIFLUPREDNATE 0.05% EYE DROP changed over time?
Over the history we have for it, the NADAC for DIFLUPREDNATE 0.05% EYE DROP has declined 69.6%. It has been tracked across 237 weekly CMS publications since Mar 23, 2022.
What are the highest and lowest recorded NADAC prices for DIFLUPREDNATE 0.05% EYE DROP?
Since Mar 23, 2022, the NADAC for DIFLUPREDNATE 0.05% EYE DROP has ranged from a low of $7.0479 (Jun 17, 2026) to a high of $31.8469 (Apr 13, 2022), with a median of $14.3011 per ML.
Are there cheaper alternatives to DIFLUPREDNATE 0.05% EYE DROP?
No other NADAC-published product currently shares the active ingredient and strength of DIFLUPREDNATE 0.05% EYE DROP in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures DIFLUPREDNATE 0.05% EYE DROP?
DIFLUPREDNATE 0.05% EYE DROP (NDC 69238138003) is labeled by Amneal Pharmaceuticals NY LLC, and CMS classifies it as a generic product.