Product Information
MEMANTINE-DONEPEZIL ER 28-10 MG is a generic product labeled by Vitruvias Therapeutics Inc., priced at $8.4446 per EA under NDC 69680018530. Its NADAC has been published 56 times since Sep 10, 2025.
FDA first approved this application on Jul 15, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
10; 28 mg/1; mg/1
Manufacturer
Vitruvias Therapeutics Inc.NDC
69680018530
Classification
Generic
Dosage Form
CAPSULE, EXTENDED RELEASE
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
DONEPEZIL HYDROCHLORIDE; MEMANTINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA216901FDA Approved
7/15/2025
TE Code
AB
On Market Since
7/16/2025
Pharmacological Classes
Price Statistics
The NADAC for MEMANTINE-DONEPEZIL ER 28-10 MG has been published 56 times since Sep 10, 2025, and over the history we have for it it has declined 52.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.4446 per EA |
|---|---|
| All-time high | $17.6769 (Sep 10, 2025) |
| All-time low | $8.4446 (Sep 23, 2026) |
| 52-week high | $17.2222 |
| 52-week low | $8.4446 |
| Median price | $13.9386 |
| Average price | $13.7659 |
| Largest weekly change | -10.6% (Sep 23, 2026) |
| Weeks tracked | 56 |
| Tracking since | Sep 10, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Vitruvias Therapeutics Inc. manufacturer profile
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Drug market
memantine hydrochloride and donepezil hydrochloride market comparison
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Therapeutic class
Cholinesterase Inhibitor class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of MEMANTINE-DONEPEZIL ER 28-10 MG?
The current National Average Drug Acquisition Cost (NADAC) for MEMANTINE-DONEPEZIL ER 28-10 MG, manufactured by Vitruvias Therapeutics Inc., is $8.4446 per EA (NDC 69680018530), effective Sep 30, 2026.
How has the price of MEMANTINE-DONEPEZIL ER 28-10 MG changed over time?
Over the history we have for it, the NADAC for MEMANTINE-DONEPEZIL ER 28-10 MG has declined 52.2%. It has been tracked across 56 weekly CMS publications since Sep 10, 2025.
What are the highest and lowest recorded NADAC prices for MEMANTINE-DONEPEZIL ER 28-10 MG?
Since Sep 10, 2025, the NADAC for MEMANTINE-DONEPEZIL ER 28-10 MG has ranged from a low of $8.4446 (Sep 23, 2026) to a high of $17.6769 (Sep 10, 2025), with a median of $13.9386 per EA.
Are there cheaper alternatives to MEMANTINE-DONEPEZIL ER 28-10 MG?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as MEMANTINE-DONEPEZIL ER 28-10 MG in a comparable dosage form, but none are currently priced below it.
Who manufactures MEMANTINE-DONEPEZIL ER 28-10 MG?
MEMANTINE-DONEPEZIL ER 28-10 MG (NDC 69680018530) is labeled by Vitruvias Therapeutics Inc., and CMS classifies it as a generic product.