Product Information
GUANFACINE HCL ER 4 MG TABLET is a generic product labeled by Advagen Pharma Ltd., priced at $0.1762 per EA under NDC 72888022701. Its NADAC has been published 60 times since Aug 13, 2025.
FDA first approved this application on Apr 15, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
4 mg/1
Manufacturer
Advagen Pharma Ltd.NDC
72888022701
Classification
Generic
Dosage Form
TABLET, EXTENDED RELEASE
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
GUANFACINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA219689FDA Approved
4/15/2025
TE Code
AB
On Market Since
4/15/2025
Pharmacological Classes
Price Statistics
The NADAC for GUANFACINE HCL ER 4 MG TABLET has been published 60 times since Aug 13, 2025, and over the history we have for it it has declined 13.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1762 per EA |
|---|---|
| All-time high | $0.2218 (Sep 10, 2025) |
| All-time low | $0.1681 (Apr 22, 2026) |
| 52-week high | $0.2118 |
| 52-week low | $0.1681 |
| Median price | $0.1924 |
| Average price | $0.1919 |
| Largest weekly change | -9.8% (Mar 18, 2026) |
| Weeks tracked | 60 |
| Tracking since | Aug 13, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Advagen Pharma Ltd. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
GUANFACINE market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Central alpha-2 Adrenergic Agonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of GUANFACINE HCL ER 4 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for GUANFACINE HCL ER 4 MG TABLET, manufactured by Advagen Pharma Ltd., is $0.1762 per EA (NDC 72888022701), effective Sep 30, 2026.
How has the price of GUANFACINE HCL ER 4 MG TABLET changed over time?
Over the history we have for it, the NADAC for GUANFACINE HCL ER 4 MG TABLET has declined 13.4%. It has been tracked across 60 weekly CMS publications since Aug 13, 2025.
What are the highest and lowest recorded NADAC prices for GUANFACINE HCL ER 4 MG TABLET?
Since Aug 13, 2025, the NADAC for GUANFACINE HCL ER 4 MG TABLET has ranged from a low of $0.1681 (Apr 22, 2026) to a high of $0.2218 (Sep 10, 2025), with a median of $0.1924 per EA.
Are there cheaper alternatives to GUANFACINE HCL ER 4 MG TABLET?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as GUANFACINE HCL ER 4 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures GUANFACINE HCL ER 4 MG TABLET?
GUANFACINE HCL ER 4 MG TABLET (NDC 72888022701) is labeled by Advagen Pharma Ltd., and CMS classifies it as a generic product.