Product Information
GUANFACINE HCL ER 4 MG TABLET is a generic product labeled by Advagen Pharma Ltd., priced at $0.1783 per EA under NDC 72888022701. Its NADAC has been published 54 times since Aug 13, 2025.
FDA first approved this application on Apr 15, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
4 mg/1
Manufacturer
Advagen Pharma Ltd.NDC
72888022701
Classification
Generic
Dosage Form
TABLET, EXTENDED RELEASE
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
GUANFACINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA219689FDA Approved
4/15/2025
TE Code
AB
On Market Since
4/15/2025
Pharmacological Classes
Price Statistics
The NADAC for GUANFACINE HCL ER 4 MG TABLET has been published 54 times since Aug 13, 2025, and over the history we have for it it has declined 12.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1783 per EA |
|---|---|
| All-time high | $0.2218 (Sep 10, 2025) |
| All-time low | $0.1681 (Apr 22, 2026) |
| 52-week high | $0.2218 |
| 52-week low | $0.1681 |
| Median price | $0.1929 |
| Average price | $0.1934 |
| Largest weekly change | -9.8% (Mar 18, 2026) |
| Weeks tracked | 54 |
| Tracking since | Aug 13, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of GUANFACINE HCL ER 4 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for GUANFACINE HCL ER 4 MG TABLET, manufactured by Advagen Pharma Ltd., is $0.1783 per EA (NDC 72888022701), effective Aug 19, 2026.
How has the price of GUANFACINE HCL ER 4 MG TABLET changed over time?
Over the history we have for it, the NADAC for GUANFACINE HCL ER 4 MG TABLET has declined 12.3%. It has been tracked across 54 weekly CMS publications since Aug 13, 2025.
What are the highest and lowest recorded NADAC prices for GUANFACINE HCL ER 4 MG TABLET?
Since Aug 13, 2025, the NADAC for GUANFACINE HCL ER 4 MG TABLET has ranged from a low of $0.1681 (Apr 22, 2026) to a high of $0.2218 (Sep 10, 2025), with a median of $0.1929 per EA.
Are there cheaper alternatives to GUANFACINE HCL ER 4 MG TABLET?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as GUANFACINE HCL ER 4 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures GUANFACINE HCL ER 4 MG TABLET?
GUANFACINE HCL ER 4 MG TABLET (NDC 72888022701) is labeled by Advagen Pharma Ltd., and CMS classifies it as a generic product.