Tolvaptan
14 NDCs across 6 manufacturers|13 Generic,1 Brand
Tolvaptan is used to treat hyponatremia, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved on May 19, 2009, and the first generic was approved May 19, 2020. FDA's Orange Book lists 37 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $140 million on Tolvaptan across 13,000 claims for 2,256 beneficiaries.
Tolvaptan is available as 14 NDCs from 6 manufacturers (13 generic, 1 brand), with NADAC prices from $14.57 to $300.09 per EA — the most expensive product costs about 21× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
14
13G / 1B
Manufacturers
6
competing in market
Price Spread
$14.57 – $300.09
per EA
7d Activity
avg -0.3% WoW · of 14 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Ascend Laboratories, LLC manufacturer profile
Open the supplier page for the manufacturer with the strongest footprint in this market.
Lead class
Vasopressin V2 Receptor Antagonist class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
6 manufacturers producing TOLVAPTAN(1 pricing outlier)
| Drug ↕ | Price | 7d Change ↕ |
|---|---|---|
SAMSCA 15 MG TABLET | $300.0891 per EA | — |
TOLVAPTAN 30 MG TABLET | $72.5518 per EA | — |
TOLVAPTAN 30 MG TABLET | $72.5518 per EA | — |
TOLVAPTAN 30 MG TABLET | $72.5518 per EA | — |
TOLVAPTAN 30 MG TABLET | $72.5518 per EA | — |
TOLVAPTAN 30 MG TABLET | $72.5518 per EA | — |
TOLVAPTAN 30 MG TABLET | $72.5518 per EA | — |
TOLVAPTAN 30 MG TABLET | $72.5518 per EA | — |
TOLVAPTAN 15 MG TABLET | $14.5741 per EA | -0.26% |
TOLVAPTAN 15 MG TABLET | $14.5741 per EA | -0.26% |
TOLVAPTAN 15 MG TABLET | $14.5741 per EA | -0.26% |
TOLVAPTAN 15 MG TABLET | $14.5741 per EA | -0.26% |
TOLVAPTAN 15 MG TABLET | $14.5741 per EA | -0.26% |
TOLVAPTAN 15 MG TABLET | $14.5741 per EA | -0.26% |
Frequently Asked Questions
What is Tolvaptan used to treat?
Tolvaptan is used to treat hyponatremia, per the National Library of Medicine's MED-RT classification.
When did Tolvaptan become available as a generic?
FDA approved the first generic Tolvaptan (ANDA) on May 19, 2020. The Orange Book currently lists 37 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Tolvaptan?
In 2024, Medicare Part D spent $140 million on Tolvaptan across 13,000 claims for 2,256 beneficiaries.
How many Tolvaptan products are on the market?
The Tolvaptan drug market contains 14 NDCs from 6 manufacturers — 13 generic and 1 brand product.
What is the price range for Tolvaptan?
NADAC reference prices for Tolvaptan range from $14.5741 to $300.0891 per EA — the most expensive product costs about 21× the cheapest.
Is generic Tolvaptan cheaper than brand?
The average generic NADAC for Tolvaptan is $45.7929 per EA, versus $300.0891 for brand-labeled products — brand versions average about 6.6× the generic price.
Which manufacturers make Tolvaptan?
6 manufacturers list Tolvaptan in NADAC. Ranked by number of NDCs, the largest are Ascend Laboratories, LLC (4), Camber Pharmaceuticals Inc. (3), Novadoz Pharmaceuticals LLC (2), Endo USA Inc. (2), Apotex Corp. (2).
How has the price of Tolvaptan changed recently?
Over the past 7 days, 0 Tolvaptan NDCs rose and 6 fell, with a market-wide average change of -0.3%.