Product Information
ZEPBOUND 12.5 MG/0.5 ML PEN is a brand product labeled by Eli Lilly and Company, priced at $525.7374 per ML under NDC 00002246080. Its NADAC has been published 123 times since Feb 21, 2024.
Strength
12.5 mg/.5mL
Manufacturer
Eli Lilly and CompanyNDC
00002246080
Classification
Brand
Dosage Form
INJECTION, SOLUTION
Route
SUBCUTANEOUS
Last Updated
6/17/2026
Active Ingredients
TIRZEPATIDEApproval Type
New Drug (NDA)
FDA Application
NDA217806On Market Since
11/8/2023
Pharmacological Classes
Price Statistics
The NADAC for ZEPBOUND 12.5 MG/0.5 ML PEN has been published 123 times since Feb 21, 2024, and over the history we have for it it has risen 2.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $525.7374 per ML |
|---|---|
| All-time high | $542.2130 (Feb 25, 2026) |
| All-time low | $510.3780 (Sep 18, 2024) |
| 52-week high | $542.2130 |
| 52-week low | $525.7374 |
| Median price | $523.7849 |
| Average price | $520.1911 |
| Largest weekly change | +3.0% (Feb 25, 2026) |
| Weeks tracked | 123 |
| Tracking since | Feb 21, 2024 |
Generic Alternatives
The matcher finds 1 NADAC-published product sharing this drug's active ingredient, strength, and dosage form across 1 manufacturer (up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of ZEPBOUND 12.5 MG/0.5 ML PEN?
The current National Average Drug Acquisition Cost (NADAC) for ZEPBOUND 12.5 MG/0.5 ML PEN, manufactured by Eli Lilly and Company, is $525.7374 per ML (NDC 00002246080), effective Jun 24, 2026.
How has the price of ZEPBOUND 12.5 MG/0.5 ML PEN changed over time?
Over the history we have for it, the NADAC for ZEPBOUND 12.5 MG/0.5 ML PEN has risen 2.7%. It has been tracked across 123 weekly CMS publications since Feb 21, 2024.
What are the highest and lowest recorded NADAC prices for ZEPBOUND 12.5 MG/0.5 ML PEN?
Since Feb 21, 2024, the NADAC for ZEPBOUND 12.5 MG/0.5 ML PEN has ranged from a low of $510.3780 (Sep 18, 2024) to a high of $542.2130 (Feb 25, 2026), with a median of $523.7849 per ML.
Are there cheaper alternatives to ZEPBOUND 12.5 MG/0.5 ML PEN?
1 NADAC-published product shares the same active ingredient, strength, and dosage form as ZEPBOUND 12.5 MG/0.5 ML PEN, but none are currently priced below it.
Who manufactures ZEPBOUND 12.5 MG/0.5 ML PEN?
ZEPBOUND 12.5 MG/0.5 ML PEN (NDC 00002246080) is labeled by Eli Lilly and Company, and CMS classifies it as a brand product.
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Same classification