Product Information
ZEPBOUND 2.5 MG/0.5 ML PEN is a brand product labeled by Eli Lilly and Company, priced at $526.2042 per ML under NDC 00002250680. Its NADAC has been published 142 times since Jan 17, 2024.
FDA first approved this application on Nov 8, 2023.
Strength
2.5 mg/.5mL
Manufacturer
Eli Lilly and CompanyNDC
00002250680
Classification
Brand
Dosage Form
INJECTION, SOLUTION
Route
SUBCUTANEOUS
Effective Date
9/23/2026
Active Ingredients
TIRZEPATIDEApproval Type
New Drug (NDA)
FDA Application
NDA217806FDA Approved
11/8/2023
On Market Since
11/8/2023
Pharmacological Classes
Price Statistics
The NADAC for ZEPBOUND 2.5 MG/0.5 ML PEN has been published 142 times since Jan 17, 2024, and over the history we have for it it has risen 3.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $526.2042 per ML |
|---|---|
| All-time high | $542.2826 (Feb 25, 2026) |
| All-time low | $508.2843 (Jan 17, 2024) |
| 52-week high | $542.2826 |
| 52-week low | $525.9515 |
| Median price | $525.9515 |
| Average price | $520.2670 |
| Largest weekly change | +3.0% (Feb 25, 2026) |
| Weeks tracked | 142 |
| Tracking since | Jan 17, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Eli Lilly and Company manufacturer profile
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Drug market
tirzepatide market comparison
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Therapeutic class
GLP-1 Receptor Agonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ZEPBOUND 2.5 MG/0.5 ML PEN?
The current National Average Drug Acquisition Cost (NADAC) for ZEPBOUND 2.5 MG/0.5 ML PEN, manufactured by Eli Lilly and Company, is $526.2042 per ML (NDC 00002250680), effective Sep 30, 2026.
How has the price of ZEPBOUND 2.5 MG/0.5 ML PEN changed over time?
Over the history we have for it, the NADAC for ZEPBOUND 2.5 MG/0.5 ML PEN has risen 3.5%. It has been tracked across 142 weekly CMS publications since Jan 17, 2024.
What are the highest and lowest recorded NADAC prices for ZEPBOUND 2.5 MG/0.5 ML PEN?
Since Jan 17, 2024, the NADAC for ZEPBOUND 2.5 MG/0.5 ML PEN has ranged from a low of $508.2843 (Jan 17, 2024) to a high of $542.2826 (Feb 25, 2026), with a median of $525.9515 per ML.
Are there cheaper alternatives to ZEPBOUND 2.5 MG/0.5 ML PEN?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as ZEPBOUND 2.5 MG/0.5 ML PEN in a comparable dosage form, but none are currently priced below it.
Who manufactures ZEPBOUND 2.5 MG/0.5 ML PEN?
ZEPBOUND 2.5 MG/0.5 ML PEN (NDC 00002250680) is labeled by Eli Lilly and Company, and CMS classifies it as a brand product.