Product Information
REFRESH PLUS 0.5% EYE DROPS is a brand product labeled by Allergan, Inc., priced at $0.2764 per EA under NDC 00023040350. Its NADAC has been published 515 times since Nov 28, 2013.
The High Outlier badge above means this manufacturer's average price in the carboxymethylcellulose sodium market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
5 mg/mL
Manufacturer
Allergan, Inc.NDC
00023040350
Classification
Brand
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
1/21/2026
Active Ingredients
CARBOXYMETHYLCELLULOSE SODIUMApproval Type
OTC MONOGRAPH DRUG
FDA Application
M018On Market Since
10/9/1996
Price Statistics
The NADAC for REFRESH PLUS 0.5% EYE DROPS has been published 515 times since Nov 28, 2013, and over the history we have for it it has risen 15.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2764 per EA |
|---|---|
| All-time high | $0.2818 (Feb 13, 2019) |
| All-time low | $0.2332 (Jan 22, 2014) |
| 52-week high | $0.2764 |
| 52-week low | $0.2764 |
| Median price | $0.2609 |
| Average price | $0.2617 |
| Largest weekly change | +12.1% (Mar 12, 2014) |
| Weeks tracked | 515 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 41% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Allergan, Inc. manufacturer profile
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Drug market
carboxymethylcellulose sodium market comparison
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of REFRESH PLUS 0.5% EYE DROPS?
The current National Average Drug Acquisition Cost (NADAC) for REFRESH PLUS 0.5% EYE DROPS, manufactured by Allergan, Inc., is $0.2764 per EA (NDC 00023040350), effective Sep 30, 2026.
How has the price of REFRESH PLUS 0.5% EYE DROPS changed over time?
Over the history we have for it, the NADAC for REFRESH PLUS 0.5% EYE DROPS has risen 15.8%. It has been tracked across 515 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for REFRESH PLUS 0.5% EYE DROPS?
Since Nov 28, 2013, the NADAC for REFRESH PLUS 0.5% EYE DROPS has ranged from a low of $0.2332 (Jan 22, 2014) to a high of $0.2818 (Feb 13, 2019), with a median of $0.2609 per EA.
Are there cheaper alternatives to REFRESH PLUS 0.5% EYE DROPS?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CARBOXYMETHYLCELL 0.5% EYE DRP, is $0.1628 per EA — about 41% below REFRESH PLUS 0.5% EYE DROPS.
Who manufactures REFRESH PLUS 0.5% EYE DROPS?
REFRESH PLUS 0.5% EYE DROPS (NDC 00023040350) is labeled by Allergan, Inc., and CMS classifies it as a brand product.