Product Information
LOMOTIL 2.5-0.025 MG TABLET is a brand product labeled by Pfizer Inc., priced at $3.0028 per EA under NDC 00025006131. Its NADAC has been published 360 times since Nov 28, 2013.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AA.
The High Outlier badge above means this manufacturer's average price in the diphenoxylate hydrochloride and atropine sulfate market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
.025; 2.5 mg/1; mg/1
Manufacturer
Pfizer Inc.NDC
00025006131
Classification
Brand
Dosage Form
TABLET
Route
ORAL
Effective Date
1/1/2026
Active Ingredients
ATROPINE SULFATE; DIPHENOXYLATE HYDROCHLORIDEApproval Type
New Drug (NDA)
FDA Application
NDA012462FDA Approved
Before 1982
TE Code
AA
On Market Since
9/15/1960
Pharmacological Classes
Price Statistics
The NADAC for LOMOTIL 2.5-0.025 MG TABLET has been published 360 times since Nov 28, 2013, and over the history we have for it it has risen 128.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.0028 per EA |
|---|---|
| All-time high | $3.0028 (Mar 11, 2026) |
| All-time low | $1.3173 (Nov 28, 2013) |
| 52-week high | $3.0028 |
| 52-week low | $2.9239 |
| Median price | $2.3057 |
| Average price | $2.2846 |
| Largest weekly change | +9.4% (Jan 10, 2018) |
| Weeks tracked | 360 |
| Tracking since | Nov 28, 2013 |
1W
N/A
1M
N/A
3M
N/A
6M
0.0%
1Y
+2.7%
3Y
+8.7%
5Y
+8.7%
All
+128.0%
Last surveyed Mar 11, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 95% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of LOMOTIL 2.5-0.025 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for LOMOTIL 2.5-0.025 MG TABLET, manufactured by Pfizer Inc., is $3.0028 per EA (NDC 00025006131), effective Mar 11, 2026.
How has the price of LOMOTIL 2.5-0.025 MG TABLET changed over time?
Over the history we have for it, the NADAC for LOMOTIL 2.5-0.025 MG TABLET has risen 128.0%. It has been tracked across 360 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for LOMOTIL 2.5-0.025 MG TABLET?
Since Nov 28, 2013, the NADAC for LOMOTIL 2.5-0.025 MG TABLET has ranged from a low of $1.3173 (Nov 28, 2013) to a high of $3.0028 (Mar 11, 2026), with a median of $2.3057 per EA.
Are there cheaper alternatives to LOMOTIL 2.5-0.025 MG TABLET?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, DIPHENOXYLATE-ATROPINE 2.5-0.025 MG TABLET, is $0.1386 per EA — about 95% below LOMOTIL 2.5-0.025 MG TABLET.
Who manufactures LOMOTIL 2.5-0.025 MG TABLET?
LOMOTIL 2.5-0.025 MG TABLET (NDC 00025006131) is labeled by Pfizer Inc., and CMS classifies it as a brand product.