Product Information
LOMOTIL 2.5-0.025 MG TABLET is a brand product labeled by Pfizer Inc., priced at $2.9910 per EA under NDC 00025006131. Its NADAC has been published 362 times since Nov 28, 2013.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AA.
The High Outlier badge above means this manufacturer's average price in the diphenoxylate hydrochloride and atropine sulfate market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
.025; 2.5 mg/1; mg/1
Manufacturer
Pfizer Inc.NDC
00025006131
Classification
Brand
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ATROPINE SULFATE; DIPHENOXYLATE HYDROCHLORIDEApproval Type
New Drug (NDA)
FDA Application
NDA012462FDA Approved
Before 1982
TE Code
AA
On Market Since
9/15/1960
Pharmacological Classes
Price Statistics
The NADAC for LOMOTIL 2.5-0.025 MG TABLET has been published 362 times since Nov 28, 2013, and over the history we have for it it has risen 127.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.9910 per EA |
|---|---|
| All-time high | $3.0028 (Mar 11, 2026) |
| All-time low | $1.3173 (Nov 28, 2013) |
| 52-week high | $3.0028 |
| 52-week low | $2.9239 |
| Median price | $2.3057 |
| Average price | $2.2885 |
| Largest weekly change | +9.4% (Jan 10, 2018) |
| Weeks tracked | 362 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 95% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Pfizer Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
diphenoxylate hydrochloride and atropine sulfate market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Anticholinergic class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of LOMOTIL 2.5-0.025 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for LOMOTIL 2.5-0.025 MG TABLET, manufactured by Pfizer Inc., is $2.9910 per EA (NDC 00025006131), effective Sep 30, 2026.
How has the price of LOMOTIL 2.5-0.025 MG TABLET changed over time?
Over the history we have for it, the NADAC for LOMOTIL 2.5-0.025 MG TABLET has risen 127.1%. It has been tracked across 362 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for LOMOTIL 2.5-0.025 MG TABLET?
Since Nov 28, 2013, the NADAC for LOMOTIL 2.5-0.025 MG TABLET has ranged from a low of $1.3173 (Nov 28, 2013) to a high of $3.0028 (Mar 11, 2026), with a median of $2.3057 per EA.
Are there cheaper alternatives to LOMOTIL 2.5-0.025 MG TABLET?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, DIPHENOXYLATE-ATROPINE 2.5-0.025 MG TABLET, is $0.1389 per EA — about 95% below LOMOTIL 2.5-0.025 MG TABLET.
Who manufactures LOMOTIL 2.5-0.025 MG TABLET?
LOMOTIL 2.5-0.025 MG TABLET (NDC 00025006131) is labeled by Pfizer Inc., and CMS classifies it as a brand product.