Product Information
ZOLOFT 100 MG TABLET is a brand product labeled by Roerig, priced at $14.9470 per EA under NDC 00049491041. Its NADAC has been published 658 times since Nov 28, 2013.
FDA first approved this application on Dec 30, 1991. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the sertraline hydrochloride market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
100 mg/1
Manufacturer
RoerigNDC
00049491041
Classification
Brand
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
6/17/2026
Active Ingredients
SERTRALINE HYDROCHLORIDEApproval Type
New Drug (NDA)
FDA Application
NDA019839FDA Approved
12/30/1991
TE Code
AB
On Market Since
2/11/1992
Pharmacological Classes
Price Statistics
The NADAC for ZOLOFT 100 MG TABLET has been published 658 times since Nov 28, 2013, and over the history we have for it it has risen 206.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $14.9470 per EA |
|---|---|
| All-time high | $14.9954 (Jun 10, 2026) |
| All-time low | $4.8736 (Nov 28, 2013) |
| 52-week high | $14.9954 |
| 52-week low | $14.2271 |
| Median price | $11.1667 |
| Average price | $10.5855 |
| Largest weekly change | +9.4% (Jun 8, 2016) |
| Weeks tracked | 658 |
| Tracking since | Nov 28, 2013 |
1W
N/A
1M
N/A
3M
-0.3%
6M
+0.0%
1Y
+5.0%
3Y
+12.9%
5Y
+27.3%
All
+206.7%
Last surveyed Jul 1, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 99% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ZOLOFT 100 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for ZOLOFT 100 MG TABLET, manufactured by Roerig, is $14.9470 per EA (NDC 00049491041), effective Jul 1, 2026.
How has the price of ZOLOFT 100 MG TABLET changed over time?
Over the history we have for it, the NADAC for ZOLOFT 100 MG TABLET has risen 206.7%. It has been tracked across 658 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for ZOLOFT 100 MG TABLET?
Since Nov 28, 2013, the NADAC for ZOLOFT 100 MG TABLET has ranged from a low of $4.8736 (Nov 28, 2013) to a high of $14.9954 (Jun 10, 2026), with a median of $11.1667 per EA.
Are there cheaper alternatives to ZOLOFT 100 MG TABLET?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, SERTRALINE HCL 100 MG TABLET, is $0.0504 per EA — about 99% below ZOLOFT 100 MG TABLET.
Who manufactures ZOLOFT 100 MG TABLET?
ZOLOFT 100 MG TABLET (NDC 00049491041) is labeled by Roerig, and CMS classifies it as a brand product.