Product Information
SYSTANE 0.3-0.4% EYE DROP is a brand product labeled by Alcon Research Ltd, priced at $0.3756 per EA under NDC 00065043133. Its NADAC has been published 510 times since Nov 23, 2016.
Strength
4; 3 mg/mL; mg/mL
Manufacturer
Alcon Research LtdNDC
00065043133
Classification
Brand
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
8/19/2026
Active Ingredients
POLYETHYLENE GLYCOL 400; PROPYLENE GLYCOLApproval Type
OTC MONOGRAPH DRUG
FDA Application
M018On Market Since
10/30/2015
Price Statistics
The NADAC for SYSTANE 0.3-0.4% EYE DROP has been published 510 times since Nov 23, 2016, and over the history we have for it it has risen 19.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.3756 per EA |
|---|---|
| All-time high | $0.4900 (Mar 11, 2026) |
| All-time low | $0.3139 (Jan 23, 2019) |
| 52-week high | $0.4900 |
| 52-week low | $0.3734 |
| Median price | $0.3442 |
| Average price | $0.3488 |
| Largest weekly change | +29.1% (Dec 17, 2025) |
| Weeks tracked | 510 |
| Tracking since | Nov 23, 2016 |
1W
N/A
1M
N/A
3M
+0.5%
6M
-0.0%
1Y
+0.2%
3Y
+2.7%
5Y
+9.1%
All
+19.0%
Last surveyed Aug 26, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the polyethylene glycol and propylene glycol market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
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Manufacturer
Alcon Research Ltd manufacturer profile
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Drug market
polyethylene glycol and propylene glycol market comparison
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of SYSTANE 0.3-0.4% EYE DROP?
The current National Average Drug Acquisition Cost (NADAC) for SYSTANE 0.3-0.4% EYE DROP, manufactured by Alcon Research Ltd, is $0.3756 per EA (NDC 00065043133), effective Aug 26, 2026.
How has the price of SYSTANE 0.3-0.4% EYE DROP changed over time?
Over the history we have for it, the NADAC for SYSTANE 0.3-0.4% EYE DROP has risen 19.0%. It has been tracked across 510 weekly CMS publications since Nov 23, 2016.
What are the highest and lowest recorded NADAC prices for SYSTANE 0.3-0.4% EYE DROP?
Since Nov 23, 2016, the NADAC for SYSTANE 0.3-0.4% EYE DROP has ranged from a low of $0.3139 (Jan 23, 2019) to a high of $0.4900 (Mar 11, 2026), with a median of $0.3442 per EA.
Are there cheaper alternatives to SYSTANE 0.3-0.4% EYE DROP?
No other NADAC-published product currently shares the active ingredient and strength of SYSTANE 0.3-0.4% EYE DROP in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures SYSTANE 0.3-0.4% EYE DROP?
SYSTANE 0.3-0.4% EYE DROP (NDC 00065043133) is labeled by Alcon Research Ltd, and CMS classifies it as a brand product.