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Product Information

SYSTANE 0.3-0.4% EYE DROP is a brand product labeled by Alcon Research Ltd, priced at $0.3756 per EA under NDC 00065043133. Its NADAC has been published 509 times since Nov 23, 2016.

SYSTANE 0.3-0.4% EYE DROP

polyethylene glycol and propylene glycol
$0.3756per EA
OTC

Strength

4; 3 mg/mL; mg/mL

Manufacturer

Alcon Research Ltd

NDC

00065043133

Classification

Brand

Dosage Form

SOLUTION/ DROPS

Route

OPHTHALMIC

Effective Date

8/19/2026

Approval Type

OTC MONOGRAPH DRUG

FDA Application

M018

On Market Since

10/30/2015

Price Statistics

The NADAC for SYSTANE 0.3-0.4% EYE DROP has been published 509 times since Nov 23, 2016, and over the history we have for it it has risen 19.0%. The table below summarizes its recorded NADAC range and movement.

Current price$0.3756 per EA
All-time high$0.4900 (Mar 11, 2026)
All-time low$0.3139 (Jan 23, 2019)
52-week high$0.4900
52-week low$0.3724
Median price$0.3442
Average price$0.3488
Largest weekly change+29.1% (Dec 17, 2025)
Weeks tracked509
Tracking sinceNov 23, 2016

Price History

1W

+0.3%

1M

+0.3%

3M

+0.6%

6M

-23.3%

1Y

+0.9%

3Y

+2.3%

5Y

+9.1%

All

+19.0%

Generic Alternatives

No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the polyethylene glycol and propylene glycol market page.

Lowest-Cost Alternatives

No alternatives available

No alternatives found with the same active ingredient and strength in a comparable dosage form.

Related Drugs

Same classification

No related drugs found.

Frequently asked questions

What is the NADAC price of SYSTANE 0.3-0.4% EYE DROP?

The current National Average Drug Acquisition Cost (NADAC) for SYSTANE 0.3-0.4% EYE DROP, manufactured by Alcon Research Ltd, is $0.3756 per EA (NDC 00065043133), effective Aug 19, 2026.

How has the price of SYSTANE 0.3-0.4% EYE DROP changed over time?

Over the history we have for it, the NADAC for SYSTANE 0.3-0.4% EYE DROP has risen 19.0%. It has been tracked across 509 weekly CMS publications since Nov 23, 2016.

What are the highest and lowest recorded NADAC prices for SYSTANE 0.3-0.4% EYE DROP?

Since Nov 23, 2016, the NADAC for SYSTANE 0.3-0.4% EYE DROP has ranged from a low of $0.3139 (Jan 23, 2019) to a high of $0.4900 (Mar 11, 2026), with a median of $0.3442 per EA.

Are there cheaper alternatives to SYSTANE 0.3-0.4% EYE DROP?

No other NADAC-published product currently shares the active ingredient and strength of SYSTANE 0.3-0.4% EYE DROP in a comparable dosage form, so no direct lower-cost alternative is listed.

Who manufactures SYSTANE 0.3-0.4% EYE DROP?

SYSTANE 0.3-0.4% EYE DROP (NDC 00065043133) is labeled by Alcon Research Ltd, and CMS classifies it as a brand product.