Product Information
SYSTANE 0.3-0.4% EYE DROP is a brand product labeled by Alcon Research Ltd, priced at $0.3736 per EA under NDC 00065043133. Its NADAC has been published 501 times since Nov 23, 2016.
Strength
4; 3 mg/mL; mg/mL
Manufacturer
Alcon Research LtdNDC
00065043133
Classification
Brand
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Last Updated
6/17/2026
Active Ingredients
POLYETHYLENE GLYCOL 400; PROPYLENE GLYCOLApproval Type
OTC MONOGRAPH DRUG
FDA Application
M018On Market Since
10/30/2015
Price Statistics
The NADAC for SYSTANE 0.3-0.4% EYE DROP has been published 501 times since Nov 23, 2016, and over the history we have for it it has risen 18.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.3736 per EA |
|---|---|
| All-time high | $0.4900 (Mar 11, 2026) |
| All-time low | $0.3139 (Jan 23, 2019) |
| 52-week high | $0.4900 |
| 52-week low | $0.3715 |
| Median price | $0.3442 |
| Average price | $0.3483 |
| Largest weekly change | +29.1% (Dec 17, 2025) |
| Weeks tracked | 501 |
| Tracking since | Nov 23, 2016 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient, strength, and dosage form. Compare the broader picture on the polyethylene glycol and propylene glycol market page.
Lowest-Cost Alternatives
No alternatives available
Frequently asked questions
What is the NADAC price of SYSTANE 0.3-0.4% EYE DROP?
The current National Average Drug Acquisition Cost (NADAC) for SYSTANE 0.3-0.4% EYE DROP, manufactured by Alcon Research Ltd, is $0.3736 per EA (NDC 00065043133), effective Jun 24, 2026.
How has the price of SYSTANE 0.3-0.4% EYE DROP changed over time?
Over the history we have for it, the NADAC for SYSTANE 0.3-0.4% EYE DROP has risen 18.4%. It has been tracked across 501 weekly CMS publications since Nov 23, 2016.
What are the highest and lowest recorded NADAC prices for SYSTANE 0.3-0.4% EYE DROP?
Since Nov 23, 2016, the NADAC for SYSTANE 0.3-0.4% EYE DROP has ranged from a low of $0.3139 (Jan 23, 2019) to a high of $0.4900 (Mar 11, 2026), with a median of $0.3442 per EA.
Are there cheaper alternatives to SYSTANE 0.3-0.4% EYE DROP?
No other NADAC-published product currently shares the active ingredient, strength, and dosage form of SYSTANE 0.3-0.4% EYE DROP, so no direct lower-cost alternative is listed.
Who manufactures SYSTANE 0.3-0.4% EYE DROP?
SYSTANE 0.3-0.4% EYE DROP (NDC 00065043133) is labeled by Alcon Research Ltd, and CMS classifies it as a brand product.
Related Drugs
Same classification