Product Information
SYSTANE ULTRA 0.4-0.3% EYE DRP is a brand product labeled by Alcon Laboratories, Inc., priced at $0.5616 per ML under NDC 00065143118. Its NADAC has been published 222 times since Aug 4, 2021.
Strength
4; 3 mg/mL; mg/mL
Manufacturer
Alcon Laboratories, Inc.NDC
00065143118
Classification
Brand
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
10/22/2025
Active Ingredients
POLYETHYLENE GLYCOL 400; PROPYLENE GLYCOLApproval Type
OTC MONOGRAPH DRUG
FDA Application
M018On Market Since
10/1/2014
Price Statistics
The NADAC for SYSTANE ULTRA 0.4-0.3% EYE DRP has been published 222 times since Aug 4, 2021, and over the history we have for it it has risen 10.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.5616 per ML |
|---|---|
| All-time high | $0.5699 (Dec 13, 2023) |
| All-time low | $0.4961 (Jan 19, 2022) |
| 52-week high | $0.5616 |
| 52-week low | $0.5586 |
| Median price | $0.5464 |
| Average price | $0.5366 |
| Largest weekly change | +7.9% (Jan 18, 2023) |
| Weeks tracked | 222 |
| Tracking since | Aug 4, 2021 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
+0.5%
3Y
+2.7%
5Y
+10.1%
All
+10.1%
Last surveyed Oct 29, 2025 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of SYSTANE ULTRA 0.4-0.3% EYE DRP?
The current National Average Drug Acquisition Cost (NADAC) for SYSTANE ULTRA 0.4-0.3% EYE DRP, manufactured by Alcon Laboratories, Inc., is $0.5616 per ML (NDC 00065143118), effective Oct 29, 2025.
How has the price of SYSTANE ULTRA 0.4-0.3% EYE DRP changed over time?
Over the history we have for it, the NADAC for SYSTANE ULTRA 0.4-0.3% EYE DRP has risen 10.1%. It has been tracked across 222 weekly CMS publications since Aug 4, 2021.
What are the highest and lowest recorded NADAC prices for SYSTANE ULTRA 0.4-0.3% EYE DRP?
Since Aug 4, 2021, the NADAC for SYSTANE ULTRA 0.4-0.3% EYE DRP has ranged from a low of $0.4961 (Jan 19, 2022) to a high of $0.5699 (Dec 13, 2023), with a median of $0.5464 per ML.
Are there cheaper alternatives to SYSTANE ULTRA 0.4-0.3% EYE DRP?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as SYSTANE ULTRA 0.4-0.3% EYE DRP in a comparable dosage form, but none are currently priced below it.
Who manufactures SYSTANE ULTRA 0.4-0.3% EYE DRP?
SYSTANE ULTRA 0.4-0.3% EYE DRP (NDC 00065143118) is labeled by Alcon Laboratories, Inc., and CMS classifies it as a brand product.