Product Information
PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP is a generic product labeled by Xttrium Laboratories, Inc., priced at $0.0390 per ML under NDC 00116402416. Its NADAC has been published 71 times since May 28, 2025.
FDA first approved this application on Jan 4, 1985. Its Orange Book therapeutic-equivalence code is AA.
PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP
Promethazine Hydrochloride and Dextromethorphan HydrobromideStrength
15; 6.25 mg/5mL; mg/5mL
Manufacturer
Xttrium Laboratories, Inc.NDC
00116402416
Classification
Generic
Dosage Form
SYRUP
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
DEXTROMETHORPHAN HYDROBROMIDE; PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA088864FDA Approved
1/4/1985
TE Code
AA
On Market Since
4/7/2025
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP has been published 71 times since May 28, 2025, and over the history we have for it it has declined 19.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0390 per ML |
|---|---|
| All-time high | $0.0487 (Jun 11, 2025) |
| All-time low | $0.0377 (Jul 22, 2026) |
| 52-week high | $0.0438 |
| 52-week low | $0.0377 |
| Median price | $0.0425 |
| Average price | $0.0420 |
| Largest weekly change | -6.0% (Jul 23, 2025) |
| Weeks tracked | 71 |
| Tracking since | May 28, 2025 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Promethazine Hydrochloride and Dextromethorphan Hydrobromide market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Xttrium Laboratories, Inc. manufacturer profile
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Drug market
Promethazine Hydrochloride and Dextromethorphan Hydrobromide market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Phenothiazine class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP, manufactured by Xttrium Laboratories, Inc., is $0.0390 per ML (NDC 00116402416), effective Sep 30, 2026.
How has the price of PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP has declined 19.8%. It has been tracked across 71 weekly CMS publications since May 28, 2025.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP?
Since May 28, 2025, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP has ranged from a low of $0.0377 (Jul 22, 2026) to a high of $0.0487 (Jun 11, 2025), with a median of $0.0425 per ML.
Are there cheaper alternatives to PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP?
No other NADAC-published product currently shares the active ingredient and strength of PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP?
PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP (NDC 00116402416) is labeled by Xttrium Laboratories, Inc., and CMS classifies it as a generic product.