Product Information
PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP is a generic product labeled by Xttrium Laboratories, Inc., priced at $0.0384 per ML under NDC 00116402416. Its NADAC has been published 65 times since May 28, 2025.
FDA first approved this application on Jan 4, 1985. Its Orange Book therapeutic-equivalence code is AA.
PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP
Promethazine Hydrochloride and Dextromethorphan HydrobromideStrength
15; 6.25 mg/5mL; mg/5mL
Manufacturer
Xttrium Laboratories, Inc.NDC
00116402416
Classification
Generic
Dosage Form
SYRUP
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
DEXTROMETHORPHAN HYDROBROMIDE; PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA088864FDA Approved
1/4/1985
TE Code
AA
On Market Since
4/7/2025
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP has been published 65 times since May 28, 2025, and over the history we have for it it has declined 21.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0384 per ML |
|---|---|
| All-time high | $0.0487 (Jun 11, 2025) |
| All-time low | $0.0377 (Jul 22, 2026) |
| 52-week high | $0.0446 |
| 52-week low | $0.0377 |
| Median price | $0.0428 |
| Average price | $0.0423 |
| Largest weekly change | -6.0% (Jul 23, 2025) |
| Weeks tracked | 65 |
| Tracking since | May 28, 2025 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Promethazine Hydrochloride and Dextromethorphan Hydrobromide market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP, manufactured by Xttrium Laboratories, Inc., is $0.0384 per ML (NDC 00116402416), effective Aug 19, 2026.
How has the price of PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP has declined 21.1%. It has been tracked across 65 weekly CMS publications since May 28, 2025.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP?
Since May 28, 2025, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP has ranged from a low of $0.0377 (Jul 22, 2026) to a high of $0.0487 (Jun 11, 2025), with a median of $0.0428 per ML.
Are there cheaper alternatives to PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP?
No other NADAC-published product currently shares the active ingredient and strength of PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP?
PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP (NDC 00116402416) is labeled by Xttrium Laboratories, Inc., and CMS classifies it as a generic product.