Product Information
MIDODRINE HCL 5 MG TABLET is a generic product labeled by Upsher-Smith Laboratories LLC, priced at $0.1113 per EA under NDC 00245021201. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application on Nov 3, 2004. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The Low Outlier badge above means this manufacturer's average price in the midodrine hydrochloride market falls below Q1 − 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
5 mg/1
Manufacturer
Upsher-Smith Laboratories LLCNDC
00245021201
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
MIDODRINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA076725FDA Approved
11/3/2004
TE Code
AB
On Market Since
11/3/2004
Pharmacological Classes
Price Statistics
The NADAC for MIDODRINE HCL 5 MG TABLET has been published 671 times since Nov 28, 2013, and over the history we have for it it has declined 72.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1113 per EA |
|---|---|
| All-time high | $0.7270 (Apr 15, 2015) |
| All-time low | $0.1084 (Feb 18, 2026) |
| 52-week high | $0.1148 |
| 52-week low | $0.1084 |
| Median price | $0.3962 |
| Average price | $0.3554 |
| Largest weekly change | +49.4% (Feb 18, 2015) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 3% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Upsher-Smith Laboratories LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
midodrine hydrochloride market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
alpha-Adrenergic Agonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of MIDODRINE HCL 5 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for MIDODRINE HCL 5 MG TABLET, manufactured by Upsher-Smith Laboratories LLC, is $0.1113 per EA (NDC 00245021201), effective Sep 30, 2026.
How has the price of MIDODRINE HCL 5 MG TABLET changed over time?
Over the history we have for it, the NADAC for MIDODRINE HCL 5 MG TABLET has declined 72.3%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for MIDODRINE HCL 5 MG TABLET?
Since Nov 28, 2013, the NADAC for MIDODRINE HCL 5 MG TABLET has ranged from a low of $0.1084 (Feb 18, 2026) to a high of $0.7270 (Apr 15, 2015), with a median of $0.3962 per EA.
Are there cheaper alternatives to MIDODRINE HCL 5 MG TABLET?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, MIDODRINE HCL 5 MG TABLET, is $0.1084 per EA — about 3% below MIDODRINE HCL 5 MG TABLET.
Who manufactures MIDODRINE HCL 5 MG TABLET?
MIDODRINE HCL 5 MG TABLET (NDC 00245021201) is labeled by Upsher-Smith Laboratories LLC, and CMS classifies it as a generic product.