Product Information
METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $1.3598 per EA under NDC 00378044501. Its NADAC has been published 79 times since Nov 28, 2013.
FDA first approved this application on Aug 20, 2004. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB
metoprolol tartrate and hydrochlorothiazideStrength
50; 100 mg/1; mg/1
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378044501
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
HYDROCHLOROTHIAZIDE; METOPROLOL TARTRATEApproval Type
Generic (ANDA)
FDA Application
ANDA076792FDA Approved
8/20/2004
TE Code
AB
On Market Since
8/20/2004
Pharmacological Classes
Price Statistics
The NADAC for METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB has been published 79 times since Nov 28, 2013, and over the history we have for it it has declined 8.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.3598 per EA |
|---|---|
| All-time high | $1.5446 (May 13, 2015) |
| All-time low | $1.3598 (Sep 23, 2026) |
| 52-week high | $1.3598 |
| 52-week low | $1.3598 |
| Median price | $1.5446 |
| Average price | $1.5260 |
| Largest weekly change | -12.0% (Sep 23, 2026) |
| Weeks tracked | 79 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the metoprolol tartrate and hydrochlorothiazide market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Mylan Pharmaceuticals Inc. manufacturer profile
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Drug market
metoprolol tartrate and hydrochlorothiazide market comparison
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Therapeutic class
Thiazide Diuretic class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB, manufactured by Mylan Pharmaceuticals Inc., is $1.3598 per EA (NDC 00378044501), effective Sep 30, 2026.
How has the price of METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB changed over time?
Over the history we have for it, the NADAC for METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB has declined 8.4%. It has been tracked across 79 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB?
Since Nov 28, 2013, the NADAC for METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB has ranged from a low of $1.3598 (Sep 23, 2026) to a high of $1.5446 (May 13, 2015), with a median of $1.5446 per EA.
Are there cheaper alternatives to METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB?
No other NADAC-published product currently shares the active ingredient and strength of METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB?
METOPROLOL-HYDROCHLOROTHIAZIDE 100-50 MG TAB (NDC 00378044501) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.