Product Information

ATOVAQUONE-PROGUANIL 250-100 MG TABLET is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $1.4777 per EA under NDC 00378416201. Its NADAC has been published 632 times since Jul 16, 2014.

FDA first approved this application on May 27, 2014. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.

The Low Outlier badge above means this manufacturer's average price in the atovaquone and proguanil hydrochloride market falls below Q1 − 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.

ATOVAQUONE-PROGUANIL 250-100 MG TABLET

atovaquone and proguanil hydrochloride
$1.4777per EA
Low Outlier

Strength

250; 100 mg/1; mg/1

NDC

00378416201

Classification

Generic

Dosage Form

TABLET, FILM COATED

Route

ORAL

Effective Date

8/19/2026

Approval Type

Generic (ANDA)

FDA Application

ANDA202362

FDA Approved

5/27/2014

TE Code

AB

On Market Since

5/28/2014

Pharmacological Classes

Antimalarial
Antimalarial
Antiprotozoal
Dihydrofolate Reductase Inhibitors

Price Statistics

The NADAC for ATOVAQUONE-PROGUANIL 250-100 MG TABLET has been published 632 times since Jul 16, 2014, and over the history we have for it it has declined 72.1%. The table below summarizes its recorded NADAC range and movement.

Current price$1.4777 per EA
All-time high$5.4053 (Jun 10, 2015)
All-time low$1.2534 (Nov 20, 2024)
52-week high$1.7306
52-week low$1.4777
Median price$2.6554
Average price$2.9826
Largest weekly change+67.1% (Feb 22, 2023)
Weeks tracked632
Tracking sinceJul 16, 2014

Price History

1W

-5.1%

1M

-5.1%

3M

-5.7%

6M

-5.8%

1Y

-11.9%

3Y

-32.5%

5Y

-49.1%

All

-72.1%

Generic Alternatives

The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Frequently asked questions

What is the NADAC price of ATOVAQUONE-PROGUANIL 250-100 MG TABLET?

The current National Average Drug Acquisition Cost (NADAC) for ATOVAQUONE-PROGUANIL 250-100 MG TABLET, manufactured by Mylan Pharmaceuticals Inc., is $1.4777 per EA (NDC 00378416201), effective Aug 19, 2026.

How has the price of ATOVAQUONE-PROGUANIL 250-100 MG TABLET changed over time?

Over the history we have for it, the NADAC for ATOVAQUONE-PROGUANIL 250-100 MG TABLET has declined 72.1%. It has been tracked across 632 weekly CMS publications since Jul 16, 2014.

What are the highest and lowest recorded NADAC prices for ATOVAQUONE-PROGUANIL 250-100 MG TABLET?

Since Jul 16, 2014, the NADAC for ATOVAQUONE-PROGUANIL 250-100 MG TABLET has ranged from a low of $1.2534 (Nov 20, 2024) to a high of $5.4053 (Jun 10, 2015), with a median of $2.6554 per EA.

Are there cheaper alternatives to ATOVAQUONE-PROGUANIL 250-100 MG TABLET?

2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ATOVAQUONE-PROGUANIL 250-100 MG TABLET in a comparable dosage form, but none are currently priced below it.

Who manufactures ATOVAQUONE-PROGUANIL 250-100 MG TABLET?

ATOVAQUONE-PROGUANIL 250-100 MG TABLET (NDC 00378416201) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.