Historical record - last NADAC effective date: 4/17/2024

Product Information

MALARONE 250-100 MG TABLET is a brand product labeled by GlaxoSmithKline LLC, priced at $6.6105 per EA under NDC 00173067501. Its NADAC has been published 126 times since Nov 28, 2013.

FDA first approved this application on Jul 14, 2000. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.

The High Outlier badge above means this manufacturer's average price in the atovaquone and proguanil hydrochloride market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.

MALARONE 250-100 MG TABLET

atovaquone and proguanil hydrochloride
$6.6105per EA
High Outlier

Strength

250; 100 mg/1; mg/1

NDC

00173067501

Classification

Brand

Dosage Form

TABLET, FILM COATED

Route

ORAL

Effective Date

4/17/2024

Approval Type

New Drug (NDA)

FDA Application

NDA021078

FDA Approved

7/14/2000

TE Code

AB

On Market Since

7/26/2000

Pharmacological Classes

Antimalarial
Antimalarial
Antiprotozoal
Dihydrofolate Reductase Inhibitors

Price Statistics

The NADAC for MALARONE 250-100 MG TABLET has been published 126 times since Nov 28, 2013, and over the history we have for it it has declined 2.2%. The table below summarizes its recorded NADAC range and movement.

Current price$6.6105 per EA
All-time high$6.7562 (Mar 12, 2014)
All-time low$6.5747 (Mar 19, 2014)
Median price$6.6105
Average price$6.6128
Largest weekly change-2.7% (Mar 19, 2014)
Weeks tracked126
Tracking sinceNov 28, 2013

Price History

1W

N/A

1M

N/A

3M

N/A

6M

N/A

1Y

N/A

3Y

+0.5%

5Y

+0.5%

All

-2.2%

Last surveyed Apr 16, 2025 — this NDC no longer appears in the current weekly NADAC file.

Generic Alternatives

The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 78% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Frequently asked questions

What is the NADAC price of MALARONE 250-100 MG TABLET?

The current National Average Drug Acquisition Cost (NADAC) for MALARONE 250-100 MG TABLET, manufactured by GlaxoSmithKline LLC, is $6.6105 per EA (NDC 00173067501), effective Apr 16, 2025.

How has the price of MALARONE 250-100 MG TABLET changed over time?

Over the history we have for it, the NADAC for MALARONE 250-100 MG TABLET has declined 2.2%. It has been tracked across 126 weekly CMS publications since Nov 28, 2013.

What are the highest and lowest recorded NADAC prices for MALARONE 250-100 MG TABLET?

Since Nov 28, 2013, the NADAC for MALARONE 250-100 MG TABLET has ranged from a low of $6.5747 (Mar 19, 2014) to a high of $6.7562 (Mar 12, 2014), with a median of $6.6105 per EA.

Are there cheaper alternatives to MALARONE 250-100 MG TABLET?

Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ATOVAQUONE-PROGUANIL 250-100 MG TABLET, is $1.4777 per EA — about 78% below MALARONE 250-100 MG TABLET.

Who manufactures MALARONE 250-100 MG TABLET?

MALARONE 250-100 MG TABLET (NDC 00173067501) is labeled by GlaxoSmithKline LLC, and CMS classifies it as a brand product.