Product Information
DIFLUPREDNATE 0.05% EYE DROP is a generic product labeled by Sandoz Inc., priced at $9.6866 per ML under NDC 00781600078. Its NADAC has been published 250 times since Dec 22, 2021.
FDA first approved this application on Jun 23, 2008. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/mL
Manufacturer
Sandoz Inc.NDC
00781600078
Classification
Generic
Dosage Form
EMULSION
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
DIFLUPREDNATEApproval Type
Authorized Generic (NDA)
FDA Application
NDA022212FDA Approved
6/23/2008
TE Code
AB
On Market Since
5/15/2013
Price Statistics
The NADAC for DIFLUPREDNATE 0.05% EYE DROP has been published 250 times since Dec 22, 2021, and over the history we have for it it has declined 70.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $9.6866 per ML |
|---|---|
| All-time high | $33.3087 (Jan 12, 2022) |
| All-time low | $7.0479 (Jun 17, 2026) |
| 52-week high | $10.4599 |
| 52-week low | $7.0479 |
| Median price | $14.6848 |
| Average price | $16.0777 |
| Largest weekly change | +46.0% (Aug 21, 2024) |
| Weeks tracked | 250 |
| Tracking since | Dec 22, 2021 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
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Same classification
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Manufacturer
Sandoz Inc. manufacturer profile
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of DIFLUPREDNATE 0.05% EYE DROP?
The current National Average Drug Acquisition Cost (NADAC) for DIFLUPREDNATE 0.05% EYE DROP, manufactured by Sandoz Inc., is $9.6866 per ML (NDC 00781600078), effective Sep 30, 2026.
How has the price of DIFLUPREDNATE 0.05% EYE DROP changed over time?
Over the history we have for it, the NADAC for DIFLUPREDNATE 0.05% EYE DROP has declined 70.9%. It has been tracked across 250 weekly CMS publications since Dec 22, 2021.
What are the highest and lowest recorded NADAC prices for DIFLUPREDNATE 0.05% EYE DROP?
Since Dec 22, 2021, the NADAC for DIFLUPREDNATE 0.05% EYE DROP has ranged from a low of $7.0479 (Jun 17, 2026) to a high of $33.3087 (Jan 12, 2022), with a median of $14.6848 per ML.
Are there cheaper alternatives to DIFLUPREDNATE 0.05% EYE DROP?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as DIFLUPREDNATE 0.05% EYE DROP in a comparable dosage form, but none are currently priced below it.
Who manufactures DIFLUPREDNATE 0.05% EYE DROP?
DIFLUPREDNATE 0.05% EYE DROP (NDC 00781600078) is labeled by Sandoz Inc., and CMS classifies it as a generic product.