Product Information
HYDROCORTISONE VAL 0.2% CREAM is a generic product labeled by Encube Ethicals, Inc., priced at $0.3292 per GM under NDC 21922000706. Its NADAC has been published 154 times since Dec 14, 2022.
FDA first approved this application on Nov 4, 2021. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922000706
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
11/19/2025
Active Ingredients
HYDROCORTISONE VALERATEApproval Type
Generic (ANDA)
FDA Application
ANDA211047FDA Approved
11/4/2021
TE Code
AB
On Market Since
12/31/2022
Pharmacological Classes
Price Statistics
The NADAC for HYDROCORTISONE VAL 0.2% CREAM has been published 154 times since Dec 14, 2022, and over the history we have for it it has declined 21.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.3292 per GM |
|---|---|
| All-time high | $0.6651 (Jul 12, 2023) |
| All-time low | $0.2120 (Jul 17, 2024) |
| 52-week high | $0.3532 |
| 52-week low | $0.3292 |
| Median price | $0.3052 |
| Average price | $0.3400 |
| Largest weekly change | -54.1% (Jul 19, 2023) |
| Weeks tracked | 154 |
| Tracking since | Dec 14, 2022 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
-6.8%
3Y
+7.9%
5Y
N/A
All
-21.5%
Last surveyed Nov 19, 2025 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 20% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
hydrocortisone valerate cream market comparison
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Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of HYDROCORTISONE VAL 0.2% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for HYDROCORTISONE VAL 0.2% CREAM, manufactured by Encube Ethicals, Inc., is $0.3292 per GM (NDC 21922000706), effective Nov 19, 2025.
How has the price of HYDROCORTISONE VAL 0.2% CREAM changed over time?
Over the history we have for it, the NADAC for HYDROCORTISONE VAL 0.2% CREAM has declined 21.5%. It has been tracked across 154 weekly CMS publications since Dec 14, 2022.
What are the highest and lowest recorded NADAC prices for HYDROCORTISONE VAL 0.2% CREAM?
Since Dec 14, 2022, the NADAC for HYDROCORTISONE VAL 0.2% CREAM has ranged from a low of $0.2120 (Jul 17, 2024) to a high of $0.6651 (Jul 12, 2023), with a median of $0.3052 per GM.
Are there cheaper alternatives to HYDROCORTISONE VAL 0.2% CREAM?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, HYDROCORTISONE VAL 0.2% CREAM, is $0.2627 per GM — about 20% below HYDROCORTISONE VAL 0.2% CREAM.
Who manufactures HYDROCORTISONE VAL 0.2% CREAM?
HYDROCORTISONE VAL 0.2% CREAM (NDC 21922000706) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.