Product Information
BUPROPION HCL XL 450 MG TABLET is a generic product labeled by Upsher-Smith Laboratories LLC, priced at $7.9956 per EA under NDC 24979024806. Its NADAC has been published 140 times since Jan 31, 2024.
FDA first approved this application on Nov 10, 2011.
The High Outlier badge above means this manufacturer's average price in the bupropion hydrochloride market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
450 mg/1
Manufacturer
Upsher-Smith Laboratories LLCNDC
24979024806
Classification
Generic
Dosage Form
TABLET, FILM COATED, EXTENDED RELEASE
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
BUPROPION HYDROCHLORIDEApproval Type
Authorized Generic (NDA)
FDA Application
NDA022497FDA Approved
11/10/2011
On Market Since
12/15/2023
Pharmacological Classes
Price Statistics
The NADAC for BUPROPION HCL XL 450 MG TABLET has been published 140 times since Jan 31, 2024, and over the history we have for it it has declined 10.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $7.9956 per EA |
|---|---|
| All-time high | $8.8913 (Feb 14, 2024) |
| All-time low | $5.5246 (Nov 20, 2024) |
| 52-week high | $8.3176 |
| 52-week low | $7.1491 |
| Median price | $7.5343 |
| Average price | $7.2583 |
| Largest weekly change | +33.5% (Jun 19, 2024) |
| Weeks tracked | 140 |
| Tracking since | Jan 31, 2024 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 6% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Upsher-Smith Laboratories LLC manufacturer profile
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Drug market
bupropion hydrochloride market comparison
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Therapeutic class
Aminoketone class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BUPROPION HCL XL 450 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUPROPION HCL XL 450 MG TABLET, manufactured by Upsher-Smith Laboratories LLC, is $7.9956 per EA (NDC 24979024806), effective Sep 30, 2026.
How has the price of BUPROPION HCL XL 450 MG TABLET changed over time?
Over the history we have for it, the NADAC for BUPROPION HCL XL 450 MG TABLET has declined 10.1%. It has been tracked across 140 weekly CMS publications since Jan 31, 2024.
What are the highest and lowest recorded NADAC prices for BUPROPION HCL XL 450 MG TABLET?
Since Jan 31, 2024, the NADAC for BUPROPION HCL XL 450 MG TABLET has ranged from a low of $5.5246 (Nov 20, 2024) to a high of $8.8913 (Feb 14, 2024), with a median of $7.5343 per EA.
Are there cheaper alternatives to BUPROPION HCL XL 450 MG TABLET?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, BUPROPION HCL XL 450 MG TABLET, is $7.5194 per EA — about 6% below BUPROPION HCL XL 450 MG TABLET.
Who manufactures BUPROPION HCL XL 450 MG TABLET?
BUPROPION HCL XL 450 MG TABLET (NDC 24979024806) is labeled by Upsher-Smith Laboratories LLC, and CMS classifies it as a generic product.