Product Information
BUPROPION HCL XL 450 MG TABLET is a generic product labeled by Alvogen Inc., priced at $7.5194 per EA under NDC 47781063730. Its NADAC has been published 332 times since Oct 23, 2019.
FDA first approved this application on Nov 10, 2011.
The High Outlier badge above means this manufacturer's average price in the bupropion hydrochloride market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
450 mg/1
Manufacturer
Alvogen Inc.NDC
47781063730
Classification
Generic
Dosage Form
TABLET, FILM COATED, EXTENDED RELEASE
Route
ORAL
Effective Date
2/18/2026
Active Ingredients
BUPROPION HYDROCHLORIDEApproval Type
Authorized Generic (NDA)
FDA Application
NDA022497FDA Approved
11/10/2011
On Market Since
9/28/2018
Pharmacological Classes
Price Statistics
The NADAC for BUPROPION HCL XL 450 MG TABLET has been published 332 times since Oct 23, 2019, and over the history we have for it it has declined 19.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $7.5194 per EA |
|---|---|
| All-time high | $11.1049 (May 13, 2020) |
| All-time low | $5.5246 (Nov 20, 2024) |
| 52-week high | $8.3176 |
| 52-week low | $7.1491 |
| Median price | $8.6581 |
| Average price | $8.4214 |
| Largest weekly change | +33.5% (Jun 19, 2024) |
| Weeks tracked | 332 |
| Tracking since | Oct 23, 2019 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
+5.2%
3Y
-8.4%
5Y
-17.6%
All
-19.7%
Last surveyed Feb 25, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Alvogen Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
bupropion hydrochloride market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Aminoketone class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BUPROPION HCL XL 450 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUPROPION HCL XL 450 MG TABLET, manufactured by Alvogen Inc., is $7.5194 per EA (NDC 47781063730), effective Feb 25, 2026.
How has the price of BUPROPION HCL XL 450 MG TABLET changed over time?
Over the history we have for it, the NADAC for BUPROPION HCL XL 450 MG TABLET has declined 19.7%. It has been tracked across 332 weekly CMS publications since Oct 23, 2019.
What are the highest and lowest recorded NADAC prices for BUPROPION HCL XL 450 MG TABLET?
Since Oct 23, 2019, the NADAC for BUPROPION HCL XL 450 MG TABLET has ranged from a low of $5.5246 (Nov 20, 2024) to a high of $11.1049 (May 13, 2020), with a median of $8.6581 per EA.
Are there cheaper alternatives to BUPROPION HCL XL 450 MG TABLET?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as BUPROPION HCL XL 450 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures BUPROPION HCL XL 450 MG TABLET?
BUPROPION HCL XL 450 MG TABLET (NDC 47781063730) is labeled by Alvogen Inc., and CMS classifies it as a generic product.