Product Information
PROTRIPTYLINE HCL 5 MG TABLET is a generic product labeled by Epic Pharma LLC, priced at $2.6182 per EA under NDC 42806009630. Its NADAC has been published 182 times since Feb 17, 2021.
FDA first approved this application on Nov 19, 2012. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
5 mg/1
Manufacturer
Epic Pharma LLCNDC
42806009630
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
PROTRIPTYLINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA202220FDA Approved
11/19/2012
TE Code
AB
On Market Since
1/9/2013
Pharmacological Classes
Price Statistics
The NADAC for PROTRIPTYLINE HCL 5 MG TABLET has been published 182 times since Feb 17, 2021, and over the history we have for it it has held within roughly two percent of its current level. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.6182 per EA |
|---|---|
| All-time high | $3.8178 (Mar 12, 2025) |
| All-time low | $2.3723 (May 22, 2024) |
| 52-week high | $3.0285 |
| 52-week low | $2.5420 |
| Median price | $2.6627 |
| Average price | $2.8424 |
| Largest weekly change | -28.7% (Apr 23, 2025) |
| Weeks tracked | 182 |
| Tracking since | Feb 17, 2021 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Epic Pharma LLC manufacturer profile
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Drug market
Protriptyline Hydrochloride market comparison
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Therapeutic class
Tricyclic Antidepressant class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PROTRIPTYLINE HCL 5 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for PROTRIPTYLINE HCL 5 MG TABLET, manufactured by Epic Pharma LLC, is $2.6182 per EA (NDC 42806009630), effective Sep 30, 2026.
How has the price of PROTRIPTYLINE HCL 5 MG TABLET changed over time?
Over the history we have for it, the NADAC for PROTRIPTYLINE HCL 5 MG TABLET has held within roughly two percent of its current level. It has been tracked across 182 weekly CMS publications since Feb 17, 2021.
What are the highest and lowest recorded NADAC prices for PROTRIPTYLINE HCL 5 MG TABLET?
Since Feb 17, 2021, the NADAC for PROTRIPTYLINE HCL 5 MG TABLET has ranged from a low of $2.3723 (May 22, 2024) to a high of $3.8178 (Mar 12, 2025), with a median of $2.6627 per EA.
Are there cheaper alternatives to PROTRIPTYLINE HCL 5 MG TABLET?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as PROTRIPTYLINE HCL 5 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures PROTRIPTYLINE HCL 5 MG TABLET?
PROTRIPTYLINE HCL 5 MG TABLET (NDC 42806009630) is labeled by Epic Pharma LLC, and CMS classifies it as a generic product.