Product Information
DEMECLOCYCLINE 300 MG TABLET is a generic product labeled by Epic Pharma LLC, priced at $3.0457 per EA under NDC 42806014448. Its NADAC has been published 356 times since Feb 10, 2016.
FDA first approved this application on Aug 18, 2015. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
300 mg/1
Manufacturer
Epic Pharma LLCNDC
42806014448
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
DEMECLOCYCLINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA065447FDA Approved
8/18/2015
TE Code
AB
On Market Since
2/2/2015
Pharmacological Classes
Price Statistics
The NADAC for DEMECLOCYCLINE 300 MG TABLET has been published 356 times since Feb 10, 2016, and over the history we have for it it has declined 68.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.0457 per EA |
|---|---|
| All-time high | $9.9346 (Dec 15, 2021) |
| All-time low | $3.0457 (Sep 23, 2026) |
| 52-week high | $5.9961 |
| 52-week low | $3.0457 |
| Median price | $6.2676 |
| Average price | $6.8082 |
| Largest weekly change | +86.9% (Dec 23, 2020) |
| Weeks tracked | 356 |
| Tracking since | Feb 10, 2016 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Epic Pharma LLC manufacturer profile
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Drug market
Demeclocycline Hydrochloride market comparison
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Therapeutic class
Tetracycline-class Antimicrobial class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DEMECLOCYCLINE 300 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for DEMECLOCYCLINE 300 MG TABLET, manufactured by Epic Pharma LLC, is $3.0457 per EA (NDC 42806014448), effective Sep 30, 2026.
How has the price of DEMECLOCYCLINE 300 MG TABLET changed over time?
Over the history we have for it, the NADAC for DEMECLOCYCLINE 300 MG TABLET has declined 68.1%. It has been tracked across 356 weekly CMS publications since Feb 10, 2016.
What are the highest and lowest recorded NADAC prices for DEMECLOCYCLINE 300 MG TABLET?
Since Feb 10, 2016, the NADAC for DEMECLOCYCLINE 300 MG TABLET has ranged from a low of $3.0457 (Sep 23, 2026) to a high of $9.9346 (Dec 15, 2021), with a median of $6.2676 per EA.
Are there cheaper alternatives to DEMECLOCYCLINE 300 MG TABLET?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as DEMECLOCYCLINE 300 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures DEMECLOCYCLINE 300 MG TABLET?
DEMECLOCYCLINE 300 MG TABLET (NDC 42806014448) is labeled by Epic Pharma LLC, and CMS classifies it as a generic product.