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Product Information

SM ANTI-ITCH 2% CREAM is a generic product labeled by Strategic Sourcing Services LLC, priced at $0.1296 per GM under NDC 49348085472. Its NADAC has been published 637 times since Nov 28, 2013.

SM ANTI-ITCH 2% CREAM

diphenhydramine hydrochloride and zinc acetate
$0.1296per GM
Discontinued
OTC

Strength

20; 1 mg/g; mg/g

NDC

49348085472

Classification

Generic

Dosage Form

CREAM

Route

TOPICAL

Effective Date

1/21/2026

Approval Type

OTC MONOGRAPH DRUG

FDA Application

M017

On Market Since

9/20/2005

Pharmacological Classes

Copper Absorption Inhibitor
Decreased Copper Ion Absorption
Histamine H1 Receptor Antagonists
Histamine-1 Receptor Antagonist

Price Statistics

The NADAC for SM ANTI-ITCH 2% CREAM has been published 637 times since Nov 28, 2013, and over the history we have for it it has risen 91.9%. The table below summarizes its recorded NADAC range and movement.

Current price$0.1296 per GM
All-time high$0.1296 (Feb 4, 2026)
All-time low$0.0588 (Dec 17, 2014)
52-week high$0.1296
52-week low$0.1296
Median price$0.0703
Average price$0.0733
Largest weekly change+20.0% (Jun 22, 2016)
Weeks tracked637
Tracking sinceNov 28, 2013

Price History

1W

N/A

1M

N/A

3M

N/A

6M

N/A

1Y

0.0%

3Y

+69.4%

5Y

+71.9%

All

+91.9%

Last surveyed Feb 4, 2026 — this NDC no longer appears in the current weekly NADAC file.

Generic Alternatives

No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the diphenhydramine hydrochloride and zinc acetate market page.

Lowest-Cost Alternatives

No alternatives available

No alternatives found with the same active ingredient and strength in a comparable dosage form.

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Frequently asked questions

What is the NADAC price of SM ANTI-ITCH 2% CREAM?

The current National Average Drug Acquisition Cost (NADAC) for SM ANTI-ITCH 2% CREAM, manufactured by Strategic Sourcing Services LLC, is $0.1296 per GM (NDC 49348085472), effective Feb 4, 2026.

How has the price of SM ANTI-ITCH 2% CREAM changed over time?

Over the history we have for it, the NADAC for SM ANTI-ITCH 2% CREAM has risen 91.9%. It has been tracked across 637 weekly CMS publications since Nov 28, 2013.

What are the highest and lowest recorded NADAC prices for SM ANTI-ITCH 2% CREAM?

Since Nov 28, 2013, the NADAC for SM ANTI-ITCH 2% CREAM has ranged from a low of $0.0588 (Dec 17, 2014) to a high of $0.1296 (Feb 4, 2026), with a median of $0.0703 per GM.

Are there cheaper alternatives to SM ANTI-ITCH 2% CREAM?

No other NADAC-published product currently shares the active ingredient and strength of SM ANTI-ITCH 2% CREAM in a comparable dosage form, so no direct lower-cost alternative is listed.

Who manufactures SM ANTI-ITCH 2% CREAM?

SM ANTI-ITCH 2% CREAM (NDC 49348085472) is labeled by Strategic Sourcing Services LLC, and CMS classifies it as a generic product.