Product Information
NAPROXEN-ESOMEPRAZ DR 375-20 MG is a generic product labeled by ScieGen Pharmaceuticals Inc., priced at $2.8990 per EA under NDC 50228043760. Its NADAC has been published 98 times since Oct 9, 2024.
FDA first approved this application on Oct 11, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
20; 375 mg/1; mg/1
Manufacturer
ScieGen Pharmaceuticals Inc.NDC
50228043760
Classification
Generic
Dosage Form
TABLET, DELAYED RELEASE
Route
ORAL
Effective Date
7/22/2026
Active Ingredients
ESOMEPRAZOLE MAGNESIUM; NAPROXENApproval Type
Generic (ANDA)
FDA Application
ANDA217738FDA Approved
10/11/2023
TE Code
AB
On Market Since
10/11/2023
Pharmacological Classes
Price Statistics
The NADAC for NAPROXEN-ESOMEPRAZ DR 375-20 MG has been published 98 times since Oct 9, 2024, and over the history we have for it it has declined 33.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.8990 per EA |
|---|---|
| All-time high | $5.0004 (Dec 11, 2024) |
| All-time low | $1.7817 (Dec 17, 2025) |
| 52-week high | $4.2746 |
| 52-week low | $1.7817 |
| Median price | $4.2746 |
| Average price | $3.6196 |
| Largest weekly change | -55.4% (Nov 19, 2025) |
| Weeks tracked | 98 |
| Tracking since | Oct 9, 2024 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of NAPROXEN-ESOMEPRAZ DR 375-20 MG?
The current National Average Drug Acquisition Cost (NADAC) for NAPROXEN-ESOMEPRAZ DR 375-20 MG, manufactured by ScieGen Pharmaceuticals Inc., is $2.8990 per EA (NDC 50228043760), effective Aug 19, 2026.
How has the price of NAPROXEN-ESOMEPRAZ DR 375-20 MG changed over time?
Over the history we have for it, the NADAC for NAPROXEN-ESOMEPRAZ DR 375-20 MG has declined 33.7%. It has been tracked across 98 weekly CMS publications since Oct 9, 2024.
What are the highest and lowest recorded NADAC prices for NAPROXEN-ESOMEPRAZ DR 375-20 MG?
Since Oct 9, 2024, the NADAC for NAPROXEN-ESOMEPRAZ DR 375-20 MG has ranged from a low of $1.7817 (Dec 17, 2025) to a high of $5.0004 (Dec 11, 2024), with a median of $4.2746 per EA.
Are there cheaper alternatives to NAPROXEN-ESOMEPRAZ DR 375-20 MG?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as NAPROXEN-ESOMEPRAZ DR 375-20 MG in a comparable dosage form, but none are currently priced below it.
Who manufactures NAPROXEN-ESOMEPRAZ DR 375-20 MG?
NAPROXEN-ESOMEPRAZ DR 375-20 MG (NDC 50228043760) is labeled by ScieGen Pharmaceuticals Inc., and CMS classifies it as a generic product.