Product Information
NAPROXEN-ESOMEPRAZ DR 375-20 MG is a generic product labeled by ScieGen Pharmaceuticals Inc., priced at $2.8190 per EA under NDC 50228043760. Its NADAC has been published 90 times since Oct 9, 2024.
Strength
20; 375 mg/1; mg/1
Manufacturer
ScieGen Pharmaceuticals Inc.NDC
50228043760
Classification
Generic
Dosage Form
TABLET, DELAYED RELEASE
Route
ORAL
Last Updated
6/17/2026
Active Ingredients
ESOMEPRAZOLE MAGNESIUM; NAPROXENApproval Type
Generic (ANDA)
FDA Application
ANDA217738On Market Since
10/11/2023
Pharmacological Classes
Price Statistics
The NADAC for NAPROXEN-ESOMEPRAZ DR 375-20 MG has been published 90 times since Oct 9, 2024, and over the history we have for it it has declined 35.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.8190 per EA |
|---|---|
| All-time high | $5.0004 (Dec 11, 2024) |
| All-time low | $1.7817 (Dec 17, 2025) |
| 52-week high | $4.2746 |
| 52-week low | $1.7817 |
| Median price | $4.2746 |
| Average price | $3.6863 |
| Largest weekly change | -55.4% (Nov 19, 2025) |
| Weeks tracked | 90 |
| Tracking since | Oct 9, 2024 |
Generic Alternatives
The matcher finds 2 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 2 manufacturers (up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of NAPROXEN-ESOMEPRAZ DR 375-20 MG?
The current National Average Drug Acquisition Cost (NADAC) for NAPROXEN-ESOMEPRAZ DR 375-20 MG, manufactured by ScieGen Pharmaceuticals Inc., is $2.8190 per EA (NDC 50228043760), effective Jun 24, 2026.
How has the price of NAPROXEN-ESOMEPRAZ DR 375-20 MG changed over time?
Over the history we have for it, the NADAC for NAPROXEN-ESOMEPRAZ DR 375-20 MG has declined 35.6%. It has been tracked across 90 weekly CMS publications since Oct 9, 2024.
What are the highest and lowest recorded NADAC prices for NAPROXEN-ESOMEPRAZ DR 375-20 MG?
Since Oct 9, 2024, the NADAC for NAPROXEN-ESOMEPRAZ DR 375-20 MG has ranged from a low of $1.7817 (Dec 17, 2025) to a high of $5.0004 (Dec 11, 2024), with a median of $4.2746 per EA.
Are there cheaper alternatives to NAPROXEN-ESOMEPRAZ DR 375-20 MG?
2 NADAC-published products share the same active ingredient, strength, and dosage form as NAPROXEN-ESOMEPRAZ DR 375-20 MG, but none are currently priced below it.
Who manufactures NAPROXEN-ESOMEPRAZ DR 375-20 MG?
NAPROXEN-ESOMEPRAZ DR 375-20 MG (NDC 50228043760) is labeled by ScieGen Pharmaceuticals Inc., and CMS classifies it as a generic product.
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