Product Information
TIZANIDINE HCL 4 MG TABLET is a generic product labeled by AvPAK, priced at $0.0331 per EA under NDC 50268076015. Its NADAC has been published 443 times since Apr 11, 2018.
FDA first approved this application on Jul 3, 2002. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
4 mg/1
Manufacturer
AvPAKNDC
50268076015
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
TIZANIDINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA076286FDA Approved
7/3/2002
TE Code
AB
On Market Since
8/24/2017
Pharmacological Classes
Price Statistics
The NADAC for TIZANIDINE HCL 4 MG TABLET has been published 443 times since Apr 11, 2018, and over the history we have for it it has declined 62.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0331 per EA |
|---|---|
| All-time high | $0.0891 (Apr 11, 2018) |
| All-time low | $0.0299 (May 22, 2024) |
| 52-week high | $0.0376 |
| 52-week low | $0.0319 |
| Median price | $0.0490 |
| Average price | $0.0517 |
| Largest weekly change | +40.0% (May 20, 2020) |
| Weeks tracked | 443 |
| Tracking since | Apr 11, 2018 |
Generic Alternatives
The matcher finds 6 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
AvPAK manufacturer profile
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Drug market
Tizanidine market comparison
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Therapeutic class
Central alpha-2 Adrenergic Agonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of TIZANIDINE HCL 4 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for TIZANIDINE HCL 4 MG TABLET, manufactured by AvPAK, is $0.0331 per EA (NDC 50268076015), effective Sep 30, 2026.
How has the price of TIZANIDINE HCL 4 MG TABLET changed over time?
Over the history we have for it, the NADAC for TIZANIDINE HCL 4 MG TABLET has declined 62.9%. It has been tracked across 443 weekly CMS publications since Apr 11, 2018.
What are the highest and lowest recorded NADAC prices for TIZANIDINE HCL 4 MG TABLET?
Since Apr 11, 2018, the NADAC for TIZANIDINE HCL 4 MG TABLET has ranged from a low of $0.0299 (May 22, 2024) to a high of $0.0891 (Apr 11, 2018), with a median of $0.0490 per EA.
Are there cheaper alternatives to TIZANIDINE HCL 4 MG TABLET?
6 manufacturers publish a NADAC-priced product with the same active ingredient and strength as TIZANIDINE HCL 4 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures TIZANIDINE HCL 4 MG TABLET?
TIZANIDINE HCL 4 MG TABLET (NDC 50268076015) is labeled by AvPAK, and CMS classifies it as a generic product.