Product Information
UREA 40% CREAM is a generic product labeled by Method Pharmaceuticals LLC, priced at $1.0536 per GM under NDC 58657048701. Its NADAC has been published 78 times since Apr 6, 2022.
Strength
400 mg/g
Manufacturer
Method Pharmaceuticals LLCNDC
58657048701
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/20/2025
Active Ingredients
UREAApproval Type
Unapproved
On Market Since
11/15/2021
Price Statistics
The NADAC for UREA 40% CREAM has been published 78 times since Apr 6, 2022, and over the history we have for it it has declined 23.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.0536 per GM |
|---|---|
| All-time high | $1.3822 (May 11, 2022) |
| All-time low | $1.0097 (May 22, 2024) |
| Median price | $1.0508 |
| Average price | $1.0816 |
| Largest weekly change | -15.7% (May 22, 2024) |
| Weeks tracked | 78 |
| Tracking since | Apr 6, 2022 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
N/A
3Y
-23.8%
5Y
N/A
All
-23.8%
Last surveyed Aug 27, 2025 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 86% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Method Pharmaceuticals LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Urea market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of UREA 40% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for UREA 40% CREAM, manufactured by Method Pharmaceuticals LLC, is $1.0536 per GM (NDC 58657048701), effective Aug 27, 2025.
How has the price of UREA 40% CREAM changed over time?
Over the history we have for it, the NADAC for UREA 40% CREAM has declined 23.8%. It has been tracked across 78 weekly CMS publications since Apr 6, 2022.
What are the highest and lowest recorded NADAC prices for UREA 40% CREAM?
Since Apr 6, 2022, the NADAC for UREA 40% CREAM has ranged from a low of $1.0097 (May 22, 2024) to a high of $1.3822 (May 11, 2022), with a median of $1.0508 per GM.
Are there cheaper alternatives to UREA 40% CREAM?
Yes. 4 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, UREA 40% CREAM, is $0.1462 per GM — about 86% below UREA 40% CREAM.
Who manufactures UREA 40% CREAM?
UREA 40% CREAM (NDC 58657048701) is labeled by Method Pharmaceuticals LLC, and CMS classifies it as a generic product.