Product Information
BRIMONIDINE-TIMOLOL 0.2%-0.5% is a generic product labeled by Apotex Corp., priced at $2.7175 per ML under NDC 60505058901. Its NADAC has been published 200 times since Dec 7, 2022.
FDA first approved this application on Apr 20, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; 5 mg/mL; mg/mL
Manufacturer
Apotex Corp.NDC
60505058901
Classification
Generic
Dosage Form
SOLUTION
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
BRIMONIDINE TARTRATE; TIMOLOL MALEATEApproval Type
Generic (ANDA)
FDA Application
ANDA091442FDA Approved
4/20/2022
TE Code
AB
On Market Since
10/19/2022
Pharmacological Classes
Price Statistics
The NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has been published 200 times since Dec 7, 2022, and over the history we have for it it has declined 91.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.7175 per ML |
|---|---|
| All-time high | $30.1545 (Dec 14, 2022) |
| All-time low | $2.7175 (Sep 23, 2026) |
| 52-week high | $4.4337 |
| 52-week low | $2.7175 |
| Median price | $6.9500 |
| Average price | $9.9490 |
| Largest weekly change | -37.2% (Jul 17, 2024) |
| Weeks tracked | 200 |
| Tracking since | Dec 7, 2022 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 27% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Apotex Corp. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Brimonidine Tartrate and Timolol Maleate market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
alpha-Adrenergic Agonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BRIMONIDINE-TIMOLOL 0.2%-0.5%?
The current National Average Drug Acquisition Cost (NADAC) for BRIMONIDINE-TIMOLOL 0.2%-0.5%, manufactured by Apotex Corp., is $2.7175 per ML (NDC 60505058901), effective Sep 30, 2026.
How has the price of BRIMONIDINE-TIMOLOL 0.2%-0.5% changed over time?
Over the history we have for it, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has declined 91.0%. It has been tracked across 200 weekly CMS publications since Dec 7, 2022.
What are the highest and lowest recorded NADAC prices for BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Since Dec 7, 2022, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has ranged from a low of $2.7175 (Sep 23, 2026) to a high of $30.1545 (Dec 14, 2022), with a median of $6.9500 per ML.
Are there cheaper alternatives to BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, BRIMONIDINE-TIMOLOL 0.2%-0.5%, is $1.9717 per ML — about 27% below BRIMONIDINE-TIMOLOL 0.2%-0.5%.
Who manufactures BRIMONIDINE-TIMOLOL 0.2%-0.5%?
BRIMONIDINE-TIMOLOL 0.2%-0.5% (NDC 60505058901) is labeled by Apotex Corp., and CMS classifies it as a generic product.