Product Information
BRIMONIDINE-TIMOLOL 0.2%-0.5% is a generic product labeled by Apotex Corp., priced at $2.7948 per ML under NDC 60505058901. Its NADAC has been published 194 times since Dec 7, 2022.
FDA first approved this application on Apr 20, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; 5 mg/mL; mg/mL
Manufacturer
Apotex Corp.NDC
60505058901
Classification
Generic
Dosage Form
SOLUTION
Route
OPHTHALMIC
Effective Date
8/19/2026
Active Ingredients
BRIMONIDINE TARTRATE; TIMOLOL MALEATEApproval Type
Generic (ANDA)
FDA Application
ANDA091442FDA Approved
4/20/2022
TE Code
AB
On Market Since
10/19/2022
Pharmacological Classes
Price Statistics
The NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has been published 194 times since Dec 7, 2022, and over the history we have for it it has declined 90.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.7948 per ML |
|---|---|
| All-time high | $30.1545 (Dec 14, 2022) |
| All-time low | $2.7948 (Aug 19, 2026) |
| 52-week high | $4.7280 |
| 52-week low | $2.7948 |
| Median price | $7.0873 |
| Average price | $10.1711 |
| Largest weekly change | -37.2% (Jul 17, 2024) |
| Weeks tracked | 194 |
| Tracking since | Dec 7, 2022 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 34% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of BRIMONIDINE-TIMOLOL 0.2%-0.5%?
The current National Average Drug Acquisition Cost (NADAC) for BRIMONIDINE-TIMOLOL 0.2%-0.5%, manufactured by Apotex Corp., is $2.7948 per ML (NDC 60505058901), effective Aug 19, 2026.
How has the price of BRIMONIDINE-TIMOLOL 0.2%-0.5% changed over time?
Over the history we have for it, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has declined 90.7%. It has been tracked across 194 weekly CMS publications since Dec 7, 2022.
What are the highest and lowest recorded NADAC prices for BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Since Dec 7, 2022, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has ranged from a low of $2.7948 (Aug 19, 2026) to a high of $30.1545 (Dec 14, 2022), with a median of $7.0873 per ML.
Are there cheaper alternatives to BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, BRIMONIDINE-TIMOLOL 0.2%-0.5%, is $1.8390 per ML — about 34% below BRIMONIDINE-TIMOLOL 0.2%-0.5%.
Who manufactures BRIMONIDINE-TIMOLOL 0.2%-0.5%?
BRIMONIDINE-TIMOLOL 0.2%-0.5% (NDC 60505058901) is labeled by Apotex Corp., and CMS classifies it as a generic product.