Product Information
BRIMONIDINE-TIMOLOL 0.2%-0.5% is a generic product labeled by Caplin Steriles Limited, priced at $1.9717 per ML under NDC 65145016401. Its NADAC has been published 52 times since Oct 8, 2025.
FDA first approved this application on Feb 25, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; 5 mg/mL; mg/mL
Manufacturer
Caplin Steriles LimitedNDC
65145016401
Classification
Generic
Dosage Form
SOLUTION
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
BRIMONIDINE TARTRATE; TIMOLOL MALEATEApproval Type
Generic (ANDA)
FDA Application
ANDA219093FDA Approved
2/25/2025
TE Code
AB
On Market Since
3/10/2025
Pharmacological Classes
Price Statistics
The NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has been published 52 times since Oct 8, 2025, and over the history we have for it it has declined 71.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.9717 per ML |
|---|---|
| All-time high | $6.8975 (Oct 15, 2025) |
| All-time low | $1.8390 (Aug 19, 2026) |
| 52-week high | $6.8975 |
| 52-week low | $1.8390 |
| Median price | $2.3834 |
| Average price | $3.3055 |
| Largest weekly change | -35.8% (Dec 17, 2025) |
| Weeks tracked | 52 |
| Tracking since | Oct 8, 2025 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Caplin Steriles Limited manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Brimonidine Tartrate and Timolol Maleate market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
alpha-Adrenergic Agonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BRIMONIDINE-TIMOLOL 0.2%-0.5%?
The current National Average Drug Acquisition Cost (NADAC) for BRIMONIDINE-TIMOLOL 0.2%-0.5%, manufactured by Caplin Steriles Limited, is $1.9717 per ML (NDC 65145016401), effective Sep 30, 2026.
How has the price of BRIMONIDINE-TIMOLOL 0.2%-0.5% changed over time?
Over the history we have for it, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has declined 71.4%. It has been tracked across 52 weekly CMS publications since Oct 8, 2025.
What are the highest and lowest recorded NADAC prices for BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Since Oct 8, 2025, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has ranged from a low of $1.8390 (Aug 19, 2026) to a high of $6.8975 (Oct 15, 2025), with a median of $2.3834 per ML.
Are there cheaper alternatives to BRIMONIDINE-TIMOLOL 0.2%-0.5%?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BRIMONIDINE-TIMOLOL 0.2%-0.5% in a comparable dosage form, but none are currently priced below it.
Who manufactures BRIMONIDINE-TIMOLOL 0.2%-0.5%?
BRIMONIDINE-TIMOLOL 0.2%-0.5% (NDC 65145016401) is labeled by Caplin Steriles Limited, and CMS classifies it as a generic product.