Product Information
METFORMIN HCL 500 MG/5 ML SOLN is a generic product labeled by VistaPharm, LLC, priced at $0.3829 per ML under NDC 66689031816. Its NADAC has been published 187 times since Mar 8, 2023.
FDA first approved this application on Aug 19, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
500 mg/5mL
Manufacturer
VistaPharm, LLCNDC
66689031816
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
METFORMIN HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA212677FDA Approved
8/19/2022
TE Code
AB
On Market Since
12/19/2022
Pharmacological Classes
Price Statistics
The NADAC for METFORMIN HCL 500 MG/5 ML SOLN has been published 187 times since Mar 8, 2023, and over the history we have for it it has declined 57.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.3829 per ML |
|---|---|
| All-time high | $0.9181 (Jun 14, 2023) |
| All-time low | $0.3730 (Aug 19, 2026) |
| 52-week high | $0.6576 |
| 52-week low | $0.3730 |
| Median price | $0.6576 |
| Average price | $0.6745 |
| Largest weekly change | -22.8% (May 22, 2024) |
| Weeks tracked | 187 |
| Tracking since | Mar 8, 2023 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
VistaPharm, LLC manufacturer profile
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Drug market
Metformin Hydrochloride market comparison
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Therapeutic class
Biguanide class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of METFORMIN HCL 500 MG/5 ML SOLN?
The current National Average Drug Acquisition Cost (NADAC) for METFORMIN HCL 500 MG/5 ML SOLN, manufactured by VistaPharm, LLC, is $0.3829 per ML (NDC 66689031816), effective Sep 30, 2026.
How has the price of METFORMIN HCL 500 MG/5 ML SOLN changed over time?
Over the history we have for it, the NADAC for METFORMIN HCL 500 MG/5 ML SOLN has declined 57.0%. It has been tracked across 187 weekly CMS publications since Mar 8, 2023.
What are the highest and lowest recorded NADAC prices for METFORMIN HCL 500 MG/5 ML SOLN?
Since Mar 8, 2023, the NADAC for METFORMIN HCL 500 MG/5 ML SOLN has ranged from a low of $0.3730 (Aug 19, 2026) to a high of $0.9181 (Jun 14, 2023), with a median of $0.6576 per ML.
Are there cheaper alternatives to METFORMIN HCL 500 MG/5 ML SOLN?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as METFORMIN HCL 500 MG/5 ML SOLN in a comparable dosage form, but none are currently priced below it.
Who manufactures METFORMIN HCL 500 MG/5 ML SOLN?
METFORMIN HCL 500 MG/5 ML SOLN (NDC 66689031816) is labeled by VistaPharm, LLC, and CMS classifies it as a generic product.