Product Information
FLUTICASONE-SALMETEROL 115-21 is a generic product labeled by Prasco Laboratories, priced at $20.7077 per GM under NDC 66993008796. Its NADAC has been published 172 times since Jun 21, 2023.
FDA first approved this application on Jun 8, 2006.
Strength
115; 21 ug/1; ug/1
Manufacturer
Prasco LaboratoriesNDC
66993008796
Classification
Generic
Dosage Form
AEROSOL, METERED
Route
RESPIRATORY (INHALATION)
Effective Date
9/23/2026
Active Ingredients
FLUTICASONE PROPIONATE; SALMETEROL XINAFOATEApproval Type
Authorized Generic (NDA)
FDA Application
NDA021254FDA Approved
6/8/2006
On Market Since
3/1/2023
Pharmacological Classes
Price Statistics
The NADAC for FLUTICASONE-SALMETEROL 115-21 has been published 172 times since Jun 21, 2023, and over the history we have for it it has risen 3.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $20.7077 per GM |
|---|---|
| All-time high | $21.3592 (Feb 11, 2026) |
| All-time low | $18.6711 (Jul 17, 2024) |
| 52-week high | $21.3592 |
| 52-week low | $20.3250 |
| Median price | $20.6091 |
| Average price | $20.4497 |
| Largest weekly change | -7.9% (Nov 20, 2024) |
| Weeks tracked | 172 |
| Tracking since | Jun 21, 2023 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 10% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Prasco Laboratories manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
fluticasone propionate and salmeterol xinafoate market comparison
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Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of FLUTICASONE-SALMETEROL 115-21?
The current National Average Drug Acquisition Cost (NADAC) for FLUTICASONE-SALMETEROL 115-21, manufactured by Prasco Laboratories, is $20.7077 per GM (NDC 66993008796), effective Sep 30, 2026.
How has the price of FLUTICASONE-SALMETEROL 115-21 changed over time?
Over the history we have for it, the NADAC for FLUTICASONE-SALMETEROL 115-21 has risen 3.2%. It has been tracked across 172 weekly CMS publications since Jun 21, 2023.
What are the highest and lowest recorded NADAC prices for FLUTICASONE-SALMETEROL 115-21?
Since Jun 21, 2023, the NADAC for FLUTICASONE-SALMETEROL 115-21 has ranged from a low of $18.6711 (Jul 17, 2024) to a high of $21.3592 (Feb 11, 2026), with a median of $20.6091 per GM.
Are there cheaper alternatives to FLUTICASONE-SALMETEROL 115-21?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ADVAIR HFA 115-21 MCG INHALER, is $18.7312 per GM — about 10% below FLUTICASONE-SALMETEROL 115-21.
Who manufactures FLUTICASONE-SALMETEROL 115-21?
FLUTICASONE-SALMETEROL 115-21 (NDC 66993008796) is labeled by Prasco Laboratories, and CMS classifies it as a generic product.