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Product Information

LOPERAMIDE-SIMETH 2-125 MG TAB is a generic product labeled by Camber Consumer Care, priced at $0.2867 per EA under NDC 69230032512. Its NADAC has been published 254 times since Oct 13, 2021.

FDA first approved this application on Jun 17, 2021.

LOPERAMIDE-SIMETH 2-125 MG TAB

Loperamide Hydrochloride and Simethicone
$0.2867per EA
OTC

Strength

125; 2 mg/1; mg/1

NDC

69230032512

Classification

Generic

Dosage Form

TABLET

Route

ORAL

Effective Date

8/19/2026

Approval Type

Generic (ANDA)

FDA Application

ANDA211438

FDA Approved

6/17/2021

On Market Since

6/17/2021

Pharmacological Classes

Opioid Agonist
Opioid Agonists
Skin Barrier Activity

Price Statistics

The NADAC for LOPERAMIDE-SIMETH 2-125 MG TAB has been published 254 times since Oct 13, 2021, and over the history we have for it it has risen 6.1%. The table below summarizes its recorded NADAC range and movement.

Current price$0.2867 per EA
All-time high$0.3621 (Sep 13, 2023)
All-time low$0.2638 (Jun 18, 2025)
52-week high$0.3073
52-week low$0.2743
Median price$0.2919
Average price$0.2921
Largest weekly change+21.9% (Aug 23, 2023)
Weeks tracked254
Tracking sinceOct 13, 2021

Price History

1W

-1.0%

1M

-1.0%

3M

-1.0%

6M

-5.3%

1Y

+4.5%

3Y

-3.5%

5Y

N/A

All

+6.1%

Generic Alternatives

The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Lowest-Cost Alternatives

1 alternative • Same active ingredient

LOPERAMIDE-SIMETH 2-125 MG TAB
Generic
69230032524•Camber Consumer Care
$0.2867

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per ML
ANTACID-ANTIGAS LIQUID
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70000006301•Cardinal Health
$0.0105
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FT ANTACID-ANTIGAS LIQUID
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70677106301•Strategic Sourcing Services LLC
$0.0105
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FT ANTACID-ANTIGAS LIQUID
Generic
70677106601•Strategic Sourcing Services LLC
$0.0105
per ML
QC ANTACID-ANTIGAS LIQUID
Generic
83324012112•Chain Drug Marketing Association
$0.0105
per ML

Frequently asked questions

What is the NADAC price of LOPERAMIDE-SIMETH 2-125 MG TAB?

The current National Average Drug Acquisition Cost (NADAC) for LOPERAMIDE-SIMETH 2-125 MG TAB, manufactured by Camber Consumer Care, is $0.2867 per EA (NDC 69230032512), effective Aug 19, 2026.

How has the price of LOPERAMIDE-SIMETH 2-125 MG TAB changed over time?

Over the history we have for it, the NADAC for LOPERAMIDE-SIMETH 2-125 MG TAB has risen 6.1%. It has been tracked across 254 weekly CMS publications since Oct 13, 2021.

What are the highest and lowest recorded NADAC prices for LOPERAMIDE-SIMETH 2-125 MG TAB?

Since Oct 13, 2021, the NADAC for LOPERAMIDE-SIMETH 2-125 MG TAB has ranged from a low of $0.2638 (Jun 18, 2025) to a high of $0.3621 (Sep 13, 2023), with a median of $0.2919 per EA.

Are there cheaper alternatives to LOPERAMIDE-SIMETH 2-125 MG TAB?

1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as LOPERAMIDE-SIMETH 2-125 MG TAB in a comparable dosage form, but none are currently priced below it.

Who manufactures LOPERAMIDE-SIMETH 2-125 MG TAB?

LOPERAMIDE-SIMETH 2-125 MG TAB (NDC 69230032512) is labeled by Camber Consumer Care, and CMS classifies it as a generic product.