Product Information
SERTRALINE HCL 25 MG TABLET is a generic product labeled by Exelan Pharmaceuticals Inc., priced at $0.0288 per EA under NDC 76282021205. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application on Feb 6, 2007. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25 mg/1
Manufacturer
Exelan Pharmaceuticals Inc.NDC
76282021205
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
SERTRALINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA077397FDA Approved
2/6/2007
TE Code
AB
On Market Since
8/20/2012
Pharmacological Classes
Price Statistics
The NADAC for SERTRALINE HCL 25 MG TABLET has been published 671 times since Nov 28, 2013, and over the history we have for it it has declined 50.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0288 per EA |
|---|---|
| All-time high | $0.0786 (Sep 16, 2020) |
| All-time low | $0.0282 (Aug 19, 2026) |
| 52-week high | $0.0336 |
| 52-week low | $0.0282 |
| Median price | $0.0575 |
| Average price | $0.0529 |
| Largest weekly change | +31.1% (Jul 22, 2020) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Exelan Pharmaceuticals Inc. manufacturer profile
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Drug market
Sertraline market comparison
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Therapeutic class
Serotonin Reuptake Inhibitor class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of SERTRALINE HCL 25 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for SERTRALINE HCL 25 MG TABLET, manufactured by Exelan Pharmaceuticals Inc., is $0.0288 per EA (NDC 76282021205), effective Sep 30, 2026.
How has the price of SERTRALINE HCL 25 MG TABLET changed over time?
Over the history we have for it, the NADAC for SERTRALINE HCL 25 MG TABLET has declined 50.6%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for SERTRALINE HCL 25 MG TABLET?
Since Nov 28, 2013, the NADAC for SERTRALINE HCL 25 MG TABLET has ranged from a low of $0.0282 (Aug 19, 2026) to a high of $0.0786 (Sep 16, 2020), with a median of $0.0575 per EA.
Are there cheaper alternatives to SERTRALINE HCL 25 MG TABLET?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as SERTRALINE HCL 25 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures SERTRALINE HCL 25 MG TABLET?
SERTRALINE HCL 25 MG TABLET (NDC 76282021205) is labeled by Exelan Pharmaceuticals Inc., and CMS classifies it as a generic product.