Product Information
BRIMONIDINE-TIMOLOL 0.2%-0.5% is a generic product labeled by Pacific Pharma, Inc., priced at $2.7948 per ML under NDC 82182045505. Its NADAC has been published 197 times since Nov 16, 2022.
FDA first approved this application on Oct 30, 2007. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; 5 mg/mL; mg/mL
Manufacturer
Pacific Pharma, Inc.NDC
82182045505
Classification
Generic
Dosage Form
SOLUTION/ DROPS
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
BRIMONIDINE TARTRATE; TIMOLOL MALEATEApproval Type
Authorized Generic (NDA)
FDA Application
NDA021398FDA Approved
10/30/2007
TE Code
AB
On Market Since
10/21/2022
Pharmacological Classes
Price Statistics
The NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has been published 197 times since Nov 16, 2022, and over the history we have for it it has declined 90.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.7948 per ML |
|---|---|
| All-time high | $30.1545 (Dec 14, 2022) |
| All-time low | $2.7948 (Aug 19, 2026) |
| 52-week high | $4.7280 |
| 52-week low | $2.7948 |
| Median price | $7.0873 |
| Average price | $10.4705 |
| Largest weekly change | -37.2% (Jul 17, 2024) |
| Weeks tracked | 197 |
| Tracking since | Nov 16, 2022 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 34% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of BRIMONIDINE-TIMOLOL 0.2%-0.5%?
The current National Average Drug Acquisition Cost (NADAC) for BRIMONIDINE-TIMOLOL 0.2%-0.5%, manufactured by Pacific Pharma, Inc., is $2.7948 per ML (NDC 82182045505), effective Aug 19, 2026.
How has the price of BRIMONIDINE-TIMOLOL 0.2%-0.5% changed over time?
Over the history we have for it, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has declined 90.4%. It has been tracked across 197 weekly CMS publications since Nov 16, 2022.
What are the highest and lowest recorded NADAC prices for BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Since Nov 16, 2022, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has ranged from a low of $2.7948 (Aug 19, 2026) to a high of $30.1545 (Dec 14, 2022), with a median of $7.0873 per ML.
Are there cheaper alternatives to BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, BRIMONIDINE-TIMOLOL 0.2%-0.5%, is $1.8390 per ML — about 34% below BRIMONIDINE-TIMOLOL 0.2%-0.5%.
Who manufactures BRIMONIDINE-TIMOLOL 0.2%-0.5%?
BRIMONIDINE-TIMOLOL 0.2%-0.5% (NDC 82182045505) is labeled by Pacific Pharma, Inc., and CMS classifies it as a generic product.