Product Information
BRIMONIDINE-TIMOLOL 0.2%-0.5% is a generic product labeled by Pacific Pharma, Inc., priced at $2.7175 per ML under NDC 82182045505. Its NADAC has been published 203 times since Nov 16, 2022.
FDA first approved this application on Oct 30, 2007. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; 5 mg/mL; mg/mL
Manufacturer
Pacific Pharma, Inc.NDC
82182045505
Classification
Generic
Dosage Form
SOLUTION/ DROPS
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
BRIMONIDINE TARTRATE; TIMOLOL MALEATEApproval Type
Authorized Generic (NDA)
FDA Application
NDA021398FDA Approved
10/30/2007
TE Code
AB
On Market Since
10/21/2022
Pharmacological Classes
Price Statistics
The NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has been published 203 times since Nov 16, 2022, and over the history we have for it it has declined 90.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.7175 per ML |
|---|---|
| All-time high | $30.1545 (Dec 14, 2022) |
| All-time low | $2.7175 (Sep 23, 2026) |
| 52-week high | $4.4337 |
| 52-week low | $2.7175 |
| Median price | $6.9500 |
| Average price | $10.2429 |
| Largest weekly change | -37.2% (Jul 17, 2024) |
| Weeks tracked | 203 |
| Tracking since | Nov 16, 2022 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 27% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Pacific Pharma, Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
BRIMONIDINE TARTRATE, TIMOLOL MALEATE market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
alpha-Adrenergic Agonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BRIMONIDINE-TIMOLOL 0.2%-0.5%?
The current National Average Drug Acquisition Cost (NADAC) for BRIMONIDINE-TIMOLOL 0.2%-0.5%, manufactured by Pacific Pharma, Inc., is $2.7175 per ML (NDC 82182045505), effective Sep 30, 2026.
How has the price of BRIMONIDINE-TIMOLOL 0.2%-0.5% changed over time?
Over the history we have for it, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has declined 90.7%. It has been tracked across 203 weekly CMS publications since Nov 16, 2022.
What are the highest and lowest recorded NADAC prices for BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Since Nov 16, 2022, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has ranged from a low of $2.7175 (Sep 23, 2026) to a high of $30.1545 (Dec 14, 2022), with a median of $6.9500 per ML.
Are there cheaper alternatives to BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, BRIMONIDINE-TIMOLOL 0.2%-0.5%, is $1.9717 per ML — about 27% below BRIMONIDINE-TIMOLOL 0.2%-0.5%.
Who manufactures BRIMONIDINE-TIMOLOL 0.2%-0.5%?
BRIMONIDINE-TIMOLOL 0.2%-0.5% (NDC 82182045505) is labeled by Pacific Pharma, Inc., and CMS classifies it as a generic product.