Product Information
BRIMONIDINE-TIMOLOL 0.2%-0.5% is a generic product labeled by Pacific Pharma, Inc., priced at $1.8390 per ML under NDC 82182045515. Its NADAC has been published 197 times since Nov 16, 2022.
FDA first approved this application on Oct 30, 2007. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; 5 mg/mL; mg/mL
Manufacturer
Pacific Pharma, Inc.NDC
82182045515
Classification
Generic
Dosage Form
SOLUTION/ DROPS
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
BRIMONIDINE TARTRATE; TIMOLOL MALEATEApproval Type
Authorized Generic (NDA)
FDA Application
NDA021398FDA Approved
10/30/2007
TE Code
AB
On Market Since
10/21/2022
Pharmacological Classes
Price Statistics
The NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has been published 197 times since Nov 16, 2022, and over the history we have for it it has declined 93.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.8390 per ML |
|---|---|
| All-time high | $30.7775 (Dec 14, 2022) |
| All-time low | $1.8390 (Aug 19, 2026) |
| 52-week high | $6.8975 |
| 52-week low | $1.8390 |
| Median price | $8.8093 |
| Average price | $10.3717 |
| Largest weekly change | +75.9% (Aug 21, 2024) |
| Weeks tracked | 197 |
| Tracking since | Nov 16, 2022 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of BRIMONIDINE-TIMOLOL 0.2%-0.5%?
The current National Average Drug Acquisition Cost (NADAC) for BRIMONIDINE-TIMOLOL 0.2%-0.5%, manufactured by Pacific Pharma, Inc., is $1.8390 per ML (NDC 82182045515), effective Aug 19, 2026.
How has the price of BRIMONIDINE-TIMOLOL 0.2%-0.5% changed over time?
Over the history we have for it, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has declined 93.8%. It has been tracked across 197 weekly CMS publications since Nov 16, 2022.
What are the highest and lowest recorded NADAC prices for BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Since Nov 16, 2022, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has ranged from a low of $1.8390 (Aug 19, 2026) to a high of $30.7775 (Dec 14, 2022), with a median of $8.8093 per ML.
Are there cheaper alternatives to BRIMONIDINE-TIMOLOL 0.2%-0.5%?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as BRIMONIDINE-TIMOLOL 0.2%-0.5% in a comparable dosage form, but none are currently priced below it.
Who manufactures BRIMONIDINE-TIMOLOL 0.2%-0.5%?
BRIMONIDINE-TIMOLOL 0.2%-0.5% (NDC 82182045515) is labeled by Pacific Pharma, Inc., and CMS classifies it as a generic product.