This NDC is on FDA's drug shortage list (posted Dec 15, 2021)
Reported reason: Other
Product Information
DEPO-MEDROL 400 MG/10 ML VIAL is a brand product labeled by Pharmacia & Upjohn Company LLC, priced at $9.0962 per ML under NDC 00009028003. Its NADAC has been published 368 times since Nov 28, 2013.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
40 mg/mL
Manufacturer
Pharmacia & Upjohn Company LLCNDC
00009028003
Classification
Brand
Dosage Form
INJECTION, SUSPENSION
Route
INTRALESIONAL; INTRAMUSCULAR; INTRASYNOVIAL; SOFT TISSUE
Effective Date
9/18/2024
Active Ingredients
METHYLPREDNISOLONE ACETATEApproval Type
New Drug (NDA)
FDA Application
NDA011757FDA Approved
Before 1982
TE Code
AB
On Market Since
5/28/1959
Pharmacological Classes
Price Statistics
The NADAC for DEPO-MEDROL 400 MG/10 ML VIAL has been published 368 times since Nov 28, 2013, and over the history we have for it it has risen 108.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $9.0962 per ML |
|---|---|
| All-time high | $9.5938 (Jun 12, 2024) |
| All-time low | $4.3553 (Nov 28, 2013) |
| 52-week high | $9.0962 |
| 52-week low | $9.0962 |
| Median price | $7.4400 |
| Average price | $7.1747 |
| Largest weekly change | +12.2% (Jun 8, 2016) |
| Weeks tracked | 368 |
| Tracking since | Nov 28, 2013 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
0.0%
3Y
+7.6%
5Y
+7.6%
All
+108.9%
Last surveyed Sep 10, 2025 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 36% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of DEPO-MEDROL 400 MG/10 ML VIAL?
The current National Average Drug Acquisition Cost (NADAC) for DEPO-MEDROL 400 MG/10 ML VIAL, manufactured by Pharmacia & Upjohn Company LLC, is $9.0962 per ML (NDC 00009028003), effective Sep 10, 2025.
How has the price of DEPO-MEDROL 400 MG/10 ML VIAL changed over time?
Over the history we have for it, the NADAC for DEPO-MEDROL 400 MG/10 ML VIAL has risen 108.9%. It has been tracked across 368 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for DEPO-MEDROL 400 MG/10 ML VIAL?
Since Nov 28, 2013, the NADAC for DEPO-MEDROL 400 MG/10 ML VIAL has ranged from a low of $4.3553 (Nov 28, 2013) to a high of $9.5938 (Jun 12, 2024), with a median of $7.4400 per ML.
Are there cheaper alternatives to DEPO-MEDROL 400 MG/10 ML VIAL?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, METHYLPREDNISOLONE 400 MG/10 ML, is $5.8078 per ML — about 36% below DEPO-MEDROL 400 MG/10 ML VIAL.
Who manufactures DEPO-MEDROL 400 MG/10 ML VIAL?
DEPO-MEDROL 400 MG/10 ML VIAL (NDC 00009028003) is labeled by Pharmacia & Upjohn Company LLC, and CMS classifies it as a brand product.
Is DEPO-MEDROL 400 MG/10 ML VIAL in shortage?
Yes — NDC 00009028003 is currently listed in FDA's drug shortage database (posted Dec 15, 2021). Reported reason: Other.