Methylprednisolone Acetate
21 NDCs across 7 manufacturers|15 Generic,6 Brand
Methylprednisolone Acetate is used to treat adrenal insufficiency, asthma, berylliosis, brain neoplasms, ulcerative colitis and dermatitis herpetiformis, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Jan 1, 1982. FDA's Orange Book lists 23 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $246K on Methylprednisolone Acetate across 12,000 claims for 8,876 beneficiaries.
Methylprednisolone Acetate is available as 21 NDCs from 7 manufacturers (15 generic, 6 brand), with NADAC prices from $5.81 to $13.42 per ML — the most expensive product costs about 2.3× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Active FDA drug shortage
23 Methylprednisolone Acetate presentations are currently listed in FDA's drug shortage database (first posted Dec 15, 2021). Shortages can move NADAC prices in the following weeks.
Total NDCs
21
15G / 6B
Manufacturers
7
competing in market
Price Spread
$5.81 – $13.42
per ML
7d Activity
avg -0.1% WoW · of 21 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Pharmacia & Upjohn Company LLC manufacturer profile
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Lead class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
7 manufacturers producing METHYLPREDNISOLONE ACETATE(1 pricing outlier)
| Drug ↕ | Price | 7d Change ↕ |
|---|---|---|
METHYLPREDNISOLONE 400 MG/5 ML | $13.4236 per ML | — |
METHYLPREDNISOLONE 400 MG/5 ML | $13.0533 per ML | — |
METHYLPREDNISOLONE 400 MG/5 ML | $13.0533 per ML | — |
METHYLPREDNISOLONE 400 MG/5 ML | $13.0533 per ML | — |
METHYLPREDNISOLONE 400 MG/5 ML | $13.0533 per ML | — |
METHYLPREDNISOLONE 80 MG/ML VL | $11.9243 per ML | — |
METHYLPREDNISOLONE 80 MG/ML VL | $11.9243 per ML | — |
METHYLPREDNISOLONE 80 MG/ML VL | $11.9243 per ML | — |
DEPO-MEDROL 80 MG/ML VIAL | $11.6573 per ML | +1.08% |
DEPO-MEDROL 400 MG/5 ML VIAL | $10.8023 per ML | — |
DEPO-MEDROL 400 MG/10 ML VIAL | $9.0962 per ML | — |
DEPO-MEDROL 40 MG/ML VIAL | $8.5504 per ML | — |
METHYLPREDNISOLONE 40 MG/ML VL | $7.4900 per ML | — |
METHYLPREDNISOLONE 40 MG/ML VL | $7.4900 per ML | — |
DEPO-MEDROL 40 MG/ML VIAL | $6.8271 per ML | -0.75% |
DEPO-MEDROL 40 MG/ML VIAL | $6.8271 per ML | -0.75% |
METHYLPREDNISOLONE 400 MG/10 ML | $5.8078 per ML | — |
METHYLPREDNISOLONE 400 MG/10 ML | $5.8078 per ML | — |
METHYLPREDNISOLONE 400 MG/10 ML | $5.8078 per ML | — |
METHYLPREDNISOLONE 400 MG/10 ML | $5.8078 per ML | — |
METHYLPREDNISOLONE 400 MG/10 ML | $5.8078 per ML | — |
Frequently Asked Questions
What is Methylprednisolone Acetate used to treat?
Methylprednisolone Acetate is used to treat adrenal insufficiency, asthma, berylliosis, brain neoplasms, ulcerative colitis and dermatitis herpetiformis, per the National Library of Medicine's MED-RT classification.
When did Methylprednisolone Acetate become available as a generic?
FDA approved the first generic Methylprednisolone Acetate (ANDA) on Jan 1, 1982. The Orange Book currently lists 23 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Methylprednisolone Acetate?
In 2024, Medicare Part D spent $246K on Methylprednisolone Acetate across 12,000 claims for 8,876 beneficiaries.
Is Methylprednisolone Acetate in shortage?
Yes — FDA's drug shortage database currently lists 23 Methylprednisolone Acetate presentations with status "Current", first posted Dec 15, 2021.
How many Methylprednisolone Acetate products are on the market?
The Methylprednisolone Acetate drug market contains 21 NDCs from 7 manufacturers — 15 generic and 6 brand products.
What is the price range for Methylprednisolone Acetate?
NADAC reference prices for Methylprednisolone Acetate range from $5.8078 to $13.4236 per ML — the most expensive product costs about 2.3× the cheapest.
Is generic Methylprednisolone Acetate cheaper than brand?
The average generic NADAC for Methylprednisolone Acetate is $9.6953 per ML, versus $8.9601 for brand-labeled products — brand is currently about 8% cheaper on average.
Which manufacturers make Methylprednisolone Acetate?
7 manufacturers list Methylprednisolone Acetate in NADAC. Ranked by number of NDCs, the largest are Pharmacia & Upjohn Company LLC (6), Amneal Pharmaceuticals LLC (5), Eugia US LLC (2), Endo USA Inc. (2), Sagent Pharmaceuticals (2).
How has the price of Methylprednisolone Acetate changed recently?
Over the past 7 days, 1 Methylprednisolone Acetate NDC rose and 2 fell, with a market-wide average change of -0.1%.