This NDC is on FDA's drug shortage list (posted Dec 15, 2021)
Reported reason: Demand increase for the drug
Product Information
DEPO-MEDROL 40 MG/ML VIAL is a brand product labeled by Pharmacia & Upjohn Company LLC, priced at $6.8271 per ML under NDC 00009307301. Its NADAC has been published 423 times since Nov 28, 2013.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The Low Outlier badge above means this manufacturer's average price in the methylprednisolone acetate market falls below Q1 − 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
40 mg/mL
Manufacturer
Pharmacia & Upjohn Company LLCNDC
00009307301
Classification
Brand
Dosage Form
INJECTION, SUSPENSION
Route
INTRA-ARTICULAR; INTRALESIONAL; INTRAMUSCULAR; SOFT TISSUE
Effective Date
9/23/2026
Active Ingredients
METHYLPREDNISOLONE ACETATEApproval Type
New Drug (NDA)
FDA Application
NDA011757FDA Approved
Before 1982
TE Code
AB
On Market Since
5/28/1959
Pharmacological Classes
Price Statistics
The NADAC for DEPO-MEDROL 40 MG/ML VIAL has been published 423 times since Nov 28, 2013, and over the history we have for it it has risen 23.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $6.8271 per ML |
|---|---|
| All-time high | $11.0670 (Jul 11, 2018) |
| All-time low | $5.0640 (Nov 18, 2015) |
| 52-week high | $7.5767 |
| 52-week low | $6.6865 |
| Median price | $7.2000 |
| Average price | $7.6783 |
| Largest weekly change | +56.5% (Feb 18, 2015) |
| Weeks tracked | 423 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 15% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Pharmacia & Upjohn Company LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
methylprednisolone acetate market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Corticosteroid class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DEPO-MEDROL 40 MG/ML VIAL?
The current National Average Drug Acquisition Cost (NADAC) for DEPO-MEDROL 40 MG/ML VIAL, manufactured by Pharmacia & Upjohn Company LLC, is $6.8271 per ML (NDC 00009307301), effective Sep 30, 2026.
How has the price of DEPO-MEDROL 40 MG/ML VIAL changed over time?
Over the history we have for it, the NADAC for DEPO-MEDROL 40 MG/ML VIAL has risen 23.3%. It has been tracked across 423 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for DEPO-MEDROL 40 MG/ML VIAL?
Since Nov 28, 2013, the NADAC for DEPO-MEDROL 40 MG/ML VIAL has ranged from a low of $5.0640 (Nov 18, 2015) to a high of $11.0670 (Jul 11, 2018), with a median of $7.2000 per ML.
Are there cheaper alternatives to DEPO-MEDROL 40 MG/ML VIAL?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, METHYLPREDNISOLONE 400 MG/10 ML, is $5.8078 per ML — about 15% below DEPO-MEDROL 40 MG/ML VIAL.
Who manufactures DEPO-MEDROL 40 MG/ML VIAL?
DEPO-MEDROL 40 MG/ML VIAL (NDC 00009307301) is labeled by Pharmacia & Upjohn Company LLC, and CMS classifies it as a brand product.
Is DEPO-MEDROL 40 MG/ML VIAL in shortage?
Yes — NDC 00009307301 is currently listed in FDA's drug shortage database (posted Dec 15, 2021). Reported reason: Demand increase for the drug.