Product Information
SYSTANE 0.4-0.3% EYE DROP is a brand product labeled by Alcon Laboratories, Inc., priced at $0.7018 per ML under NDC 00065042915. Its NADAC has been published 671 times since Nov 28, 2013.
Strength
4; 3 mg/mL; mg/mL
Manufacturer
Alcon Laboratories, Inc.NDC
00065042915
Classification
Brand
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
POLYETHYLENE GLYCOL 400; PROPYLENE GLYCOLApproval Type
OTC MONOGRAPH DRUG
FDA Application
M018On Market Since
2/25/2003
Price Statistics
The NADAC for SYSTANE 0.4-0.3% EYE DROP has been published 671 times since Nov 28, 2013, and over the history we have for it it has risen 25.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.7018 per ML |
|---|---|
| All-time high | $0.7018 (Sep 30, 2026) |
| All-time low | $0.5612 (Nov 28, 2013) |
| 52-week high | $0.7018 |
| 52-week low | $0.6950 |
| Median price | $0.6022 |
| Average price | $0.6258 |
| Largest weekly change | +5.9% (Feb 22, 2023) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 19% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Alcon Laboratories, Inc. manufacturer profile
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Drug market
polyethylene glycol 400 and Propylene Glycol market comparison
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Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of SYSTANE 0.4-0.3% EYE DROP?
The current National Average Drug Acquisition Cost (NADAC) for SYSTANE 0.4-0.3% EYE DROP, manufactured by Alcon Laboratories, Inc., is $0.7018 per ML (NDC 00065042915), effective Sep 30, 2026.
How has the price of SYSTANE 0.4-0.3% EYE DROP changed over time?
Over the history we have for it, the NADAC for SYSTANE 0.4-0.3% EYE DROP has risen 25.1%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for SYSTANE 0.4-0.3% EYE DROP?
Since Nov 28, 2013, the NADAC for SYSTANE 0.4-0.3% EYE DROP has ranged from a low of $0.5612 (Nov 28, 2013) to a high of $0.7018 (Sep 30, 2026), with a median of $0.6022 per ML.
Are there cheaper alternatives to SYSTANE 0.4-0.3% EYE DROP?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, SYSTANE 0.4-0.3% EYE DROP, is $0.5679 per ML — about 19% below SYSTANE 0.4-0.3% EYE DROP.
Who manufactures SYSTANE 0.4-0.3% EYE DROP?
SYSTANE 0.4-0.3% EYE DROP (NDC 00065042915) is labeled by Alcon Laboratories, Inc., and CMS classifies it as a brand product.