Product Information
SYSTANE 0.4-0.3% EYE DROP is a brand product labeled by Alcon Laboratories, Inc., priced at $0.6982 per ML under NDC 00065042915. Its NADAC has been published 665 times since Nov 28, 2013.
Strength
4; 3 mg/mL; mg/mL
Manufacturer
Alcon Laboratories, Inc.NDC
00065042915
Classification
Brand
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
8/19/2026
Active Ingredients
POLYETHYLENE GLYCOL 400; PROPYLENE GLYCOLApproval Type
OTC MONOGRAPH DRUG
FDA Application
M018On Market Since
2/25/2003
Price Statistics
The NADAC for SYSTANE 0.4-0.3% EYE DROP has been published 665 times since Nov 28, 2013, and over the history we have for it it has risen 24.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.6982 per ML |
|---|---|
| All-time high | $0.7018 (Jan 14, 2026) |
| All-time low | $0.5612 (Nov 28, 2013) |
| 52-week high | $0.7018 |
| 52-week low | $0.6950 |
| Median price | $0.6022 |
| Average price | $0.6252 |
| Largest weekly change | +5.9% (Feb 22, 2023) |
| Weeks tracked | 665 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 19% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of SYSTANE 0.4-0.3% EYE DROP?
The current National Average Drug Acquisition Cost (NADAC) for SYSTANE 0.4-0.3% EYE DROP, manufactured by Alcon Laboratories, Inc., is $0.6982 per ML (NDC 00065042915), effective Aug 19, 2026.
How has the price of SYSTANE 0.4-0.3% EYE DROP changed over time?
Over the history we have for it, the NADAC for SYSTANE 0.4-0.3% EYE DROP has risen 24.4%. It has been tracked across 665 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for SYSTANE 0.4-0.3% EYE DROP?
Since Nov 28, 2013, the NADAC for SYSTANE 0.4-0.3% EYE DROP has ranged from a low of $0.5612 (Nov 28, 2013) to a high of $0.7018 (Jan 14, 2026), with a median of $0.6022 per ML.
Are there cheaper alternatives to SYSTANE 0.4-0.3% EYE DROP?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, SYSTANE 0.4-0.3% EYE DROP, is $0.5673 per ML — about 19% below SYSTANE 0.4-0.3% EYE DROP.
Who manufactures SYSTANE 0.4-0.3% EYE DROP?
SYSTANE 0.4-0.3% EYE DROP (NDC 00065042915) is labeled by Alcon Laboratories, Inc., and CMS classifies it as a brand product.