Product Information
SYSTANE 0.4-0.3% EYE DROP is a brand product labeled by Alcon Laboratories, Inc., priced at $0.5679 per ML under NDC 00065042930. Its NADAC has been published 671 times since Nov 28, 2013.
Strength
4; 3 mg/mL; mg/mL
Manufacturer
Alcon Laboratories, Inc.NDC
00065042930
Classification
Brand
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
POLYETHYLENE GLYCOL 400; PROPYLENE GLYCOLApproval Type
OTC MONOGRAPH DRUG
FDA Application
M018On Market Since
2/25/2003
Price Statistics
The NADAC for SYSTANE 0.4-0.3% EYE DROP has been published 671 times since Nov 28, 2013, and over the history we have for it it has risen 25.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.5679 per ML |
|---|---|
| All-time high | $0.5699 (Dec 13, 2023) |
| All-time low | $0.4413 (Feb 19, 2014) |
| 52-week high | $0.5679 |
| 52-week low | $0.5598 |
| Median price | $0.4919 |
| Average price | $0.5036 |
| Largest weekly change | +7.9% (Jan 18, 2023) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Alcon Laboratories, Inc. manufacturer profile
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Drug market
polyethylene glycol 400 and Propylene Glycol market comparison
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of SYSTANE 0.4-0.3% EYE DROP?
The current National Average Drug Acquisition Cost (NADAC) for SYSTANE 0.4-0.3% EYE DROP, manufactured by Alcon Laboratories, Inc., is $0.5679 per ML (NDC 00065042930), effective Sep 30, 2026.
How has the price of SYSTANE 0.4-0.3% EYE DROP changed over time?
Over the history we have for it, the NADAC for SYSTANE 0.4-0.3% EYE DROP has risen 25.4%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for SYSTANE 0.4-0.3% EYE DROP?
Since Nov 28, 2013, the NADAC for SYSTANE 0.4-0.3% EYE DROP has ranged from a low of $0.4413 (Feb 19, 2014) to a high of $0.5699 (Dec 13, 2023), with a median of $0.4919 per ML.
Are there cheaper alternatives to SYSTANE 0.4-0.3% EYE DROP?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as SYSTANE 0.4-0.3% EYE DROP in a comparable dosage form, but none are currently priced below it.
Who manufactures SYSTANE 0.4-0.3% EYE DROP?
SYSTANE 0.4-0.3% EYE DROP (NDC 00065042930) is labeled by Alcon Laboratories, Inc., and CMS classifies it as a brand product.