Product Information
SYSTANE ULTRA 0.4-0.3% EYE DRP is a brand product labeled by Alcon Laboratories, Inc., priced at $0.4407 per EA under NDC 00065143206. Its NADAC has been published 359 times since Jun 20, 2018.
Strength
4; 3 mg/mL; mg/mL
Manufacturer
Alcon Laboratories, Inc.NDC
00065143206
Classification
Brand
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
10/22/2025
Active Ingredients
POLYETHYLENE GLYCOL 400; PROPYLENE GLYCOLApproval Type
OTC MONOGRAPH DRUG
FDA Application
M018On Market Since
7/27/2009
Price Statistics
The NADAC for SYSTANE ULTRA 0.4-0.3% EYE DRP has been published 359 times since Jun 20, 2018, and over the history we have for it it has risen 8.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4407 per EA |
|---|---|
| All-time high | $0.4568 (Oct 11, 2023) |
| All-time low | $0.3747 (Jul 18, 2018) |
| 52-week high | $0.4407 |
| 52-week low | $0.4395 |
| Median price | $0.4231 |
| Average price | $0.4211 |
| Largest weekly change | -7.4% (Jul 18, 2018) |
| Weeks tracked | 359 |
| Tracking since | Jun 20, 2018 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
+0.3%
3Y
-0.9%
5Y
+4.2%
All
+8.9%
Last surveyed Jan 28, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 18% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of SYSTANE ULTRA 0.4-0.3% EYE DRP?
The current National Average Drug Acquisition Cost (NADAC) for SYSTANE ULTRA 0.4-0.3% EYE DRP, manufactured by Alcon Laboratories, Inc., is $0.4407 per EA (NDC 00065143206), effective Jan 28, 2026.
How has the price of SYSTANE ULTRA 0.4-0.3% EYE DRP changed over time?
Over the history we have for it, the NADAC for SYSTANE ULTRA 0.4-0.3% EYE DRP has risen 8.9%. It has been tracked across 359 weekly CMS publications since Jun 20, 2018.
What are the highest and lowest recorded NADAC prices for SYSTANE ULTRA 0.4-0.3% EYE DRP?
Since Jun 20, 2018, the NADAC for SYSTANE ULTRA 0.4-0.3% EYE DRP has ranged from a low of $0.3747 (Jul 18, 2018) to a high of $0.4568 (Oct 11, 2023), with a median of $0.4231 per EA.
Are there cheaper alternatives to SYSTANE ULTRA 0.4-0.3% EYE DRP?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, SYSTANE ULTRA 0.4-0.3% EYE DRP, is $0.3601 per EA — about 18% below SYSTANE ULTRA 0.4-0.3% EYE DRP.
Who manufactures SYSTANE ULTRA 0.4-0.3% EYE DRP?
SYSTANE ULTRA 0.4-0.3% EYE DRP (NDC 00065143206) is labeled by Alcon Laboratories, Inc., and CMS classifies it as a brand product.