Product Information
ENTRESTO 49 MG-51 MG TABLET is a brand product labeled by Novartis Pharmaceuticals Corporation, priced at $11.5543 per EA under NDC 00078077767. Its NADAC has been published 558 times since Oct 21, 2015.
The High Outlier badge above means this manufacturer's average price in the Sacubitril and Valsartan market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
49; 51 mg/1; mg/1
Manufacturer
Novartis Pharmaceuticals CorporationNDC
00078077767
Classification
Brand
Dosage Form
TABLET, FILM COATED
Route
ORAL
Last Updated
6/17/2026
Active Ingredients
SACUBITRIL; VALSARTANApproval Type
New Drug (NDA)
FDA Application
NDA207620On Market Since
7/7/2015
Pharmacological Classes
Price Statistics
The NADAC for ENTRESTO 49 MG-51 MG TABLET has been published 558 times since Oct 21, 2015, and over the history we have for it it has risen 98.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $11.5543 per EA |
|---|---|
| All-time high | $11.6044 (May 13, 2026) |
| All-time low | $5.8189 (Oct 21, 2015) |
| 52-week high | $11.6044 |
| 52-week low | $11.2611 |
| Median price | $9.3169 |
| Average price | $9.0069 |
| Largest weekly change | +9.9% (Jan 23, 2019) |
| Weeks tracked | 558 |
| Tracking since | Oct 21, 2015 |
Generic Alternatives
The matcher finds 9 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 9 manufacturers (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 95% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of ENTRESTO 49 MG-51 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for ENTRESTO 49 MG-51 MG TABLET, manufactured by Novartis Pharmaceuticals Corporation, is $11.5543 per EA (NDC 00078077767), effective Jun 24, 2026.
How has the price of ENTRESTO 49 MG-51 MG TABLET changed over time?
Over the history we have for it, the NADAC for ENTRESTO 49 MG-51 MG TABLET has risen 98.6%. It has been tracked across 558 weekly CMS publications since Oct 21, 2015.
What are the highest and lowest recorded NADAC prices for ENTRESTO 49 MG-51 MG TABLET?
Since Oct 21, 2015, the NADAC for ENTRESTO 49 MG-51 MG TABLET has ranged from a low of $5.8189 (Oct 21, 2015) to a high of $11.6044 (May 13, 2026), with a median of $9.3169 per EA.
Are there cheaper alternatives to ENTRESTO 49 MG-51 MG TABLET?
Yes. 9 NADAC-published products share the same active ingredient, strength, and dosage form. The lowest-priced option, SACUBITRIL-VALSARTAN 49-51 MG, is $0.5485 per EA — about 95% below ENTRESTO 49 MG-51 MG TABLET.
Who manufactures ENTRESTO 49 MG-51 MG TABLET?
ENTRESTO 49 MG-51 MG TABLET (NDC 00078077767) is labeled by Novartis Pharmaceuticals Corporation, and CMS classifies it as a brand product.
Related Drugs
Same classification