Product Information
ENTRESTO 49 MG-51 MG TABLET is a brand product labeled by Novartis Pharmaceuticals Corporation, priced at $11.5570 per EA under NDC 00078077720. Its NADAC has been published 566 times since Oct 21, 2015.
FDA first approved this application on Jul 7, 2015. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the Sacubitril and Valsartan market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
49; 51 mg/1; mg/1
Manufacturer
Novartis Pharmaceuticals CorporationNDC
00078077720
Classification
Brand
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
SACUBITRIL; VALSARTANApproval Type
New Drug (NDA)
FDA Application
NDA207620FDA Approved
7/7/2015
TE Code
AB
On Market Since
7/7/2015
Pharmacological Classes
Price Statistics
The NADAC for ENTRESTO 49 MG-51 MG TABLET has been published 566 times since Oct 21, 2015, and over the history we have for it it has risen 98.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $11.5570 per EA |
|---|---|
| All-time high | $11.6044 (May 13, 2026) |
| All-time low | $5.8189 (Oct 21, 2015) |
| 52-week high | $11.6044 |
| 52-week low | $11.2639 |
| Median price | $9.3169 |
| Average price | $9.0429 |
| Largest weekly change | +9.9% (Jan 23, 2019) |
| Weeks tracked | 566 |
| Tracking since | Oct 21, 2015 |
Generic Alternatives
The matcher finds 9 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 95% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ENTRESTO 49 MG-51 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for ENTRESTO 49 MG-51 MG TABLET, manufactured by Novartis Pharmaceuticals Corporation, is $11.5570 per EA (NDC 00078077720), effective Aug 19, 2026.
How has the price of ENTRESTO 49 MG-51 MG TABLET changed over time?
Over the history we have for it, the NADAC for ENTRESTO 49 MG-51 MG TABLET has risen 98.6%. It has been tracked across 566 weekly CMS publications since Oct 21, 2015.
What are the highest and lowest recorded NADAC prices for ENTRESTO 49 MG-51 MG TABLET?
Since Oct 21, 2015, the NADAC for ENTRESTO 49 MG-51 MG TABLET has ranged from a low of $5.8189 (Oct 21, 2015) to a high of $11.6044 (May 13, 2026), with a median of $9.3169 per EA.
Are there cheaper alternatives to ENTRESTO 49 MG-51 MG TABLET?
Yes. 9 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, SACUBITRIL-VALSARTAN 49-51 MG, is $0.5291 per EA — about 95% below ENTRESTO 49 MG-51 MG TABLET.
Who manufactures ENTRESTO 49 MG-51 MG TABLET?
ENTRESTO 49 MG-51 MG TABLET (NDC 00078077720) is labeled by Novartis Pharmaceuticals Corporation, and CMS classifies it as a brand product.