Product Information
ADVAIR 100-50 DISKUS is a brand product labeled by GlaxoSmithKline LLC, priced at $2.4867 per EA under NDC 00173069500. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application on Aug 24, 2000. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
100; 50 ug/1; ug/1
Manufacturer
GlaxoSmithKline LLCNDC
00173069500
Classification
Brand
Dosage Form
POWDER
Route
RESPIRATORY (INHALATION)
Effective Date
9/23/2026
Active Ingredients
FLUTICASONE PROPIONATE; SALMETEROL XINAFOATEApproval Type
New Drug (NDA)
FDA Application
NDA021077FDA Approved
8/24/2000
TE Code
AB
On Market Since
2/28/2001
Pharmacological Classes
Price Statistics
The NADAC for ADVAIR 100-50 DISKUS has been published 671 times since Nov 28, 2013, and over the history we have for it it has declined 29.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.4867 per EA |
|---|---|
| All-time high | $5.0722 (Aug 14, 2019) |
| All-time low | $2.4861 (Aug 19, 2026) |
| 52-week high | $2.4896 |
| 52-week low | $2.4861 |
| Median price | $4.6587 |
| Average price | $4.2248 |
| Largest weekly change | -50.8% (Dec 27, 2023) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 57% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
GlaxoSmithKline LLC manufacturer profile
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Drug market
fluticasone propionate and salmeterol market comparison
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Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ADVAIR 100-50 DISKUS?
The current National Average Drug Acquisition Cost (NADAC) for ADVAIR 100-50 DISKUS, manufactured by GlaxoSmithKline LLC, is $2.4867 per EA (NDC 00173069500), effective Sep 30, 2026.
How has the price of ADVAIR 100-50 DISKUS changed over time?
Over the history we have for it, the NADAC for ADVAIR 100-50 DISKUS has declined 29.4%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for ADVAIR 100-50 DISKUS?
Since Nov 28, 2013, the NADAC for ADVAIR 100-50 DISKUS has ranged from a low of $2.4861 (Aug 19, 2026) to a high of $5.0722 (Aug 14, 2019), with a median of $4.6587 per EA.
Are there cheaper alternatives to ADVAIR 100-50 DISKUS?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, FLUTICASONE-SALMETEROL 100-50, is $1.0736 per EA — about 57% below ADVAIR 100-50 DISKUS.
Who manufactures ADVAIR 100-50 DISKUS?
ADVAIR 100-50 DISKUS (NDC 00173069500) is labeled by GlaxoSmithKline LLC, and CMS classifies it as a brand product.