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Product Information

METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $1.4111 per EA under NDC 00378043401. Its NADAC has been published 658 times since Nov 28, 2013.

FDA first approved this application on Aug 20, 2004. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.

METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB

metoprolol tartrate and hydrochlorothiazide
$1.4111per EA

Strength

25; 100 mg/1; mg/1

NDC

00378043401

Classification

Generic

Dosage Form

TABLET

Route

ORAL

Effective Date

9/23/2026

Approval Type

Generic (ANDA)

FDA Application

ANDA076792

FDA Approved

8/20/2004

TE Code

AB

On Market Since

8/20/2004

Pharmacological Classes

Adrenergic beta-Antagonists
Increased Diuresis
Thiazide Diuretic
Thiazides
beta-Adrenergic Blocker

Price Statistics

The NADAC for METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB has been published 658 times since Nov 28, 2013, and over the history we have for it it has risen 7.6%. The table below summarizes its recorded NADAC range and movement.

Current price$1.4111 per EA
All-time high$1.6238 (Dec 15, 2021)
All-time low$0.9383 (Oct 18, 2017)
52-week high$1.4111
52-week low$1.2341
Median price$1.3910
Average price$1.3702
Largest weekly change-23.1% (Sep 21, 2016)
Weeks tracked658
Tracking sinceNov 28, 2013

Price History

1W

0.0%

1M

+3.3%

3M

+4.4%

6M

+9.1%

1Y

+12.2%

3Y

-4.6%

5Y

-13.1%

All

+7.6%

Generic Alternatives

The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Lowest-Cost Alternatives

1 alternative • Same active ingredient

METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB
Generic
27241030201•Ajanta Pharma USA Inc.
$1.4111

Related Drugs

Same classification

HYDROCHLOROTHIAZIDE 25 MG TAB
Generic
00172208360•Teva Pharmaceuticals USA Inc.
$0.0115
per EA
HYDROCHLOROTHIAZIDE 25 MG TAB
Generic
00172208380•Teva Pharmaceuticals USA Inc.
$0.0115
per EA
HYDROCHLOROTHIAZIDE 25 MG TAB
Generic
16729018301•Accord Healthcare Inc.
$0.0115
per EA
HYDROCHLOROTHIAZIDE 25 MG TAB
Generic
16729018317•Accord Healthcare Inc.
$0.0115
per EA
HYDROCHLOROTHIAZIDE 25 MG TAB
Generic
23155000801•Heritage Pharmaceuticals Inc.
$0.0115
per EA
HYDROCHLOROTHIAZIDE 25 MG TAB
Generic
23155000810•Heritage Pharmaceuticals Inc.
$0.0115
per EA
HYDROCHLOROTHIAZIDE 25 MG TAB
Generic
29300012801•Unichem Pharmaceuticals (USA) Inc.
$0.0115
per EA
HYDROCHLOROTHIAZIDE 25 MG TAB
Generic
29300012810•Unichem Pharmaceuticals (USA) Inc.
$0.0115
per EA
HYDROCHLOROTHIAZIDE 25 MG TAB
Generic
43547039710•Solco Healthcare US LLC
$0.0115
per EA
HYDROCHLOROTHIAZIDE 25 MG TAB
Generic
43547039711•Solco Healthcare US LLC
$0.0115
per EA

Continue researching this drug

Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.

Manufacturer

Mylan Pharmaceuticals Inc. manufacturer profile

See the full portfolio, pricing trend, and other products from this labeler.

Drug market

metoprolol tartrate and hydrochlorothiazide market comparison

Compare this molecule across participating manufacturers and inspect the broader market price spread.

Therapeutic class

Thiazide Diuretic class view

See how this drug behaves alongside other products in the same FDA pharmacologic class.

Trend hub

Latest market trends

Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.

Guide

Understanding NADAC pricing

Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.

Frequently asked questions

What is the NADAC price of METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB?

The current National Average Drug Acquisition Cost (NADAC) for METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB, manufactured by Mylan Pharmaceuticals Inc., is $1.4111 per EA (NDC 00378043401), effective Sep 30, 2026.

How has the price of METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB changed over time?

Over the history we have for it, the NADAC for METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB has risen 7.6%. It has been tracked across 658 weekly CMS publications since Nov 28, 2013.

What are the highest and lowest recorded NADAC prices for METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB?

Since Nov 28, 2013, the NADAC for METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB has ranged from a low of $0.9383 (Oct 18, 2017) to a high of $1.6238 (Dec 15, 2021), with a median of $1.3910 per EA.

Are there cheaper alternatives to METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB?

1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB in a comparable dosage form, but none are currently priced below it.

Who manufactures METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB?

METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB (NDC 00378043401) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.