Product Information
METFORMIN ER 500 MG OSMOTIC TB is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $0.1383 per EA under NDC 00378600291. Its NADAC has been published 515 times since Oct 12, 2016.
FDA first approved this application on Aug 1, 2012. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
500 mg/1
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378600291
Classification
Generic
Dosage Form
TABLET, FILM COATED, EXTENDED RELEASE
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
METFORMIN HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA200690FDA Approved
8/1/2012
TE Code
AB2
On Market Since
8/23/2016
Pharmacological Classes
Price Statistics
The NADAC for METFORMIN ER 500 MG OSMOTIC TB has been published 515 times since Oct 12, 2016, and over the history we have for it it has declined 98.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1383 per EA |
|---|---|
| All-time high | $6.8383 (Oct 12, 2016) |
| All-time low | $0.1017 (Apr 22, 2026) |
| 52-week high | $0.1722 |
| 52-week low | $0.1017 |
| Median price | $1.1190 |
| Average price | $1.8551 |
| Largest weekly change | -77.1% (Feb 22, 2023) |
| Weeks tracked | 515 |
| Tracking since | Oct 12, 2016 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of METFORMIN ER 500 MG OSMOTIC TB?
The current National Average Drug Acquisition Cost (NADAC) for METFORMIN ER 500 MG OSMOTIC TB, manufactured by Mylan Pharmaceuticals Inc., is $0.1383 per EA (NDC 00378600291), effective Aug 19, 2026.
How has the price of METFORMIN ER 500 MG OSMOTIC TB changed over time?
Over the history we have for it, the NADAC for METFORMIN ER 500 MG OSMOTIC TB has declined 98.0%. It has been tracked across 515 weekly CMS publications since Oct 12, 2016.
What are the highest and lowest recorded NADAC prices for METFORMIN ER 500 MG OSMOTIC TB?
Since Oct 12, 2016, the NADAC for METFORMIN ER 500 MG OSMOTIC TB has ranged from a low of $0.1017 (Apr 22, 2026) to a high of $6.8383 (Oct 12, 2016), with a median of $1.1190 per EA.
Are there cheaper alternatives to METFORMIN ER 500 MG OSMOTIC TB?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as METFORMIN ER 500 MG OSMOTIC TB in a comparable dosage form, but none are currently priced below it.
Who manufactures METFORMIN ER 500 MG OSMOTIC TB?
METFORMIN ER 500 MG OSMOTIC TB (NDC 00378600291) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.